Journal ArticleDOI
Local immune responses following nasal delivery of an adjuvanted influenza vaccine.
Jean-Pierre Y. Scheerlinck,Susie Gekas,Hung-Hsun Yen,Stirling John Edwards,Martin J. Pearse,Alan Coulter,Phil Sutton +6 more
Reads0
Chats0
TLDR
It is shown for the first time, that following nasal vaccination, specific antibodies enter the circulation of primed animals via the draining lymphatics as a wave that peaks approximately 5-6 days after vaccination.About:
This article is published in Vaccine.The article was published on 2006-05-01. It has received 23 citations till now. The article focuses on the topics: Nasal administration & Influenza vaccine.read more
Citations
More filters
Journal ArticleDOI
ISCOMs and ISCOMATRIX.
TL;DR: ISCOMs and ISCOMATRIX vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite origin or tumor in a number of animal species including non-human primates and humans.
Journal ArticleDOI
Biomedical applications of sheep models: from asthma to vaccines.
TL;DR: The use of sheep as an animal model for human vaccine development, asthma pathogenesis and treatment, the study of neonatal development, and the optimization of drug delivery and surgical techniques is reviewed.
Journal ArticleDOI
Pharmaceutical Aspects of Intranasal Delivery of Vaccines Using Particulate Systems
TL;DR: Although particulate systems may offer potential in the nasal delivery of vaccines by enhancing uptake by antigen-presenting cells, the real success in enhancement of vaccine delivery can only be achieved by careful design and manipulation of physicochemical properties of particulate vaccine delivery systems.
Journal ArticleDOI
Needle-free influenza vaccination
TL;DR: Although various needle-free vaccination methods for influenza have shown preclinical promise, few have progressed to clinical trials-only live attenuated intranasal vaccines have received approval, and only in some countries.
Journal ArticleDOI
Nasal-nanotechnology: revolution for efficient therapeutics delivery
TL;DR: The use of nanomaterials including peptide-based nanotubes and nanogels (NGs) for vaccine delivery via nasal route is a new approach to control the disease progression.
References
More filters
Journal ArticleDOI
Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland.
Margot Mütsch,Weigong Zhou,Philip Rhodes,Matthias Bopp,Robert T. Chen,Thomas Linder,Christian Spyr,Robert Steffen +7 more
TL;DR: This study suggests a strong association between the inactivated intranasal influenza vaccine used in Switzerland and Bell's palsy.
Journal ArticleDOI
Chitosan as a novel nasal delivery system for vaccines.
TL;DR: The results of the study showed that the nasal chitosan influenza vaccine was both effective and protective according to the CPMP requirements.
Use of the Inactivated Intranasal Influenza Vaccine and the Risk of Bell's Palsy
Margot Mütsch,Weigong Zhou,Philip Rhodes,Matthias Bopp,Robert T. Chen,Thomas Linder,Christian Spyr,Robert Steffen,Berna Biotech +8 more
TL;DR: In this article, the authors conducted a matched case-control study and a case-series analysis and found that the intranasal vaccine significantly increased the risk of Bell's palsy (adjusted odds ratio, 84.0; 95 percent confidence interval, 20.1 to 351).
Journal ArticleDOI
A road less travelled: large animal models in immunological research
Wayne R. Hein,Philip J. Griebel +1 more
TL;DR: Animal research can be improved markedly by placing more emphasis on biological relevance when evaluating animal models and by taking greater advantage of the unique experimental opportunities that are offered by large animals.
Journal ArticleDOI
Effective nasal influenza vaccine delivery using chitosan.
Robert C. Read,Simone Naylor,Christopher W. Potter,Jenny Bond,Inderjit Jabbal-Gill,A. N. Fisher,Lisbeth Illum,Roy Jennings +7 more
TL;DR: Data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination.