Journal ArticleDOI
Long-range charge transfer in DNA: transient structural distortions control the distance dependence.
TLDR
A mechanism for long-range charge transport in DNA that depends on its spontaneous structural distortion, which is called phonon-assisted polaron hopping is described, which provides a framework for understanding the reactions and charge-transport properties of DNA.Abstract:
Damage to DNA is often caused by oxidative reactions. In one such process, an electron is lost from a base, forming its radical cation. Further reaction of the radical cation can lead to permanent change, which results in mutation. This Account is a report on oxidative damage to DNA caused by irradiation of anthraquinone derivatives, which are either randomly bound to the DNA or attached to it covalently at specific locations. Radical cations introduced in the DNA by the excited quinone cause damage both near to it and far away. We describe a mechanism for long-range charge transport in DNA that depends on its spontaneous structural distortion, which we call phonon-assisted polaron hopping. This mechanism, and its extension, provides a framework for understanding the reactions and charge-transport properties of DNA.read more
Citations
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Journal ArticleDOI
Challenges and opportunities for structural DNA nanotechnology
TL;DR: The technical challenges in the field of structural DNA nanotechnology are examined and some of the promising applications that could be developed if these hurdles can be overcome are outlined.
Journal ArticleDOI
Ultrafast Excited-State Dynamics in Nucleic Acids
TL;DR: The nature and dynamics of the singlet excited electronic states created in nucleic acids and their constituents by UV light are reviewed, finding that these states are highly stable to photochemical decay, perhaps as a result of selection pressure during a long period of molecular evolution.
Journal ArticleDOI
Direct and indirect effects of UV radiation on DNA and its components.
TL;DR: The main UVB- and UVA-induced DNA photoproducts, together with the mechanisms of their formation, are described and it was found that UVA photooxidation damage mostly involves the guanine residues of cellular DNA as the result of singlet oxygen generation by still unknown endogenous photosensitizers.
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Direct observation of hole transfer through DNA by hopping between adenine bases and by tunnelling
TL;DR: It is shown experimentally that the rate of charge transfer between two guanine bases decreases with increasing separation only if the guanines are separated by no more than three base pairs; if more bridging base pairs are present, the transfer rates exhibit only a weak distance dependence.
References
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Journal ArticleDOI
Oxidative Nucleobase Modifications Leading to Strand Scission
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How Easily Oxidizable Is DNA? One-Electron Reduction Potentials of Adenosine and Guanosine Radicals in Aqueous Solution
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Oxidative Strand Scission of Nucleic Acids: Routes Initiated by Hydrogen Abstraction from the Sugar Moiety.
TL;DR: This work has shown the ability to characterize the sugar moiety through the mechanism of “sugar-by-sugar interactions” and has suggested a number of mechanisms that could be responsible for the sweetness of the sucrose molecule.
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Long-range photoinduced electron transfer through a DNA helix
Catherine J. Murphy,Michelle R. Arkin,Yonchu Jenkins,Naresh D. Ghatlia,Stefan H. Bossmann,Nicholas J. Turro,Jacqueline K. Barton +6 more
TL;DR: The stacked aromatic heterocycles of the DNA duplex therefore serve as an efficient medium for coupling electron donors and acceptors over very long distances.
Journal ArticleDOI
Charge transfer and transport in DNA
TL;DR: The energetic-dynamic relations, in conjunction with the energetic data for d*/d- and for B/B+, determine the realization of the two distinct mechanisms in different hole donor systems, establishing the conditions for "chemistry at a distance" after charge transport in DNA.