Long-term colchicine treatment in children with familial mediterranean fever
TLDR
The efficacy of long-term colchicine treatment of children with FMF makes early diagnosis life saving, and side effects were insignificant, and did not prompt permanent discontinuation of treatment in any of the children.Abstract:
Three hundred fifty children (younger than age 16) who had familial Mediterranean fever (FMF) were given continuous prophylactic treatment with colchicine (1-2 mg/day) for 6-13 years. Complete remission of febrile attacks was achieved in 64% of the patients, and partial remission in 31%. Protracted attacks of arthritis virtually disappeared. None of the children developed amyloidosis while on the colchicine regimen. Side effects of colchicine were insignificant, and did not prompt permanent discontinuation of treatment in any of the children. Their growth, development, and subsequent fertility were normal. The efficacy of long-term colchicine treatment of children with FMF makes early diagnosis life saving.read more
Citations
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Colchicine in Patients with Chronic Coronary Disease
TL;DR: In a randomized trial involving patients with chronic coronary disease, the risk of cardiovascular events was significantly lower among those who received 0.5 mg of colchicine once daily than among thoseWho received placebo.
Journal ArticleDOI
Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial.
Massimo Imazio,Marco Bobbio,Enrico Cecchi,Daniela Demarie,Brunella Demichelis,Pomari F,Mauro Moratti,G. Gaschino,Massimo Giammaria,Aldo Ghisio,Riccardo Belli,Rita Trinchero +11 more
TL;DR: Colchicine plus conventional therapy led to a clinically important and statistically significant benefit over conventional treatment, decreasing the recurrence rate in patients with a first episode of acute pericarditis.
Journal ArticleDOI
Colchicine poisoning: the dark side of an ancient drug
Yaron Finkelstein,Steven E. Aks,Janine R. Hutson,David N. Juurlink,Patricia Nguyen,Gal Dubnov-Raz,Uri Pollak,Gideon Koren,Yedidia Bentur +8 more
TL;DR: Although colchicine poisoning is relatively uncommon, it is imperative to recognize its features as it is associated with a high mortality rate when missed and should be suspected in patients with access to the drug and the typical toxidrome (gastroenteritis, hypotension, lactic acidosis, and prerenal azotemia).
Journal ArticleDOI
Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health.
Jonathan Samuels,Ivona Aksentijevich,Yelizaveta Torosyan,Michael Centola,Zuoming Deng,Raman Sood,Daniel L. Kastner +6 more
TL;DR: The data suggest that ethnic background is an important predictor of finding 1 of the presently known mutations, and the knowledge of ancestries atypical for FMF can suggest the diagnosis of other hereditary periodic fever syndromes.
Journal ArticleDOI
Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations
Helen J. Lachmann,Bulent Sengul,Tugba Yavuzsen,David R. Booth,SE Booth,A Bybee,J. R. Gallimore,Müjde Soytürk,Servet Akar,Mehmet Tunca,Philip N. Hawkins +10 more
TL;DR: Substantial sub-clinical inflammation occurs widely and over prolonged periods in patients with FMF, indicating that the relatively infrequent clinically overt attacks represent the 'tip of the iceberg' in this disorder.
References
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Journal ArticleDOI
Familial Mediterranean fever. A survey of 470 cases and review of the literature
TL;DR: Familial Mediterranean fever is a genetic disorder restricted to certain ethnic groups and marked by the sporadic appearance of acute attacks and the insidious development of amyloidosis; the gamut of time-relationship between these two manifestations are best explained as expressions of a single pleiotropic gene.
Journal ArticleDOI
Colchicine in the Prevention and Treatment of the Amyloidosis of Familial Mediterranean Fever
TL;DR: It is concluded that colchicine prevented amyloidosis in the authors' high-risk population and that it can prevent additional deterioration of renal function in patients with amyloidsosis who have proteinuria but not the nephrotic syndrome.
Journal ArticleDOI
A Controlled Trial of Colchicine in Preventing Attacks of Familial Mediterranean Fever
Deborah Zemer,Moshe Revach,Mordechai Pras,Baruch Modan,Stanley Schor,Ezra Sohar,Joseph Gafni +6 more
TL;DR: A four-month, double-blind, crossover study of 22 patients with familial Mediterranean fever was undertaken to study the effect of colchicine in decreasing acute attacks of that disease.
Journal ArticleDOI
Colchicine therapy for familial mediterranean fever. A double-blind trial.
TL;DR: Eleven patients with long standing familial Mediterranean fever were studied in a double-blind trial using daily colchicine or placebo to determine the best course of action for each patient.
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