M
Michael Centola
Researcher at Oklahoma Medical Research Foundation
Publications - 125
Citations - 10029
Michael Centola is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Gene expression & Cytokine. The author has an hindex of 42, co-authored 125 publications receiving 9524 citations. Previous affiliations of Michael Centola include University of California, Santa Barbara & National Institutes of Health.
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Journal ArticleDOI
Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
Ivona Aksentijevich,Michael Centola,Zuoming Deng,Raman Sood,James E. Balow,Geryl Wood,Nurit Zaks,Elizabeth Mansfield,Xinguo Chen,S. Eisenberg,Anil Vedula,Neta Shafran,Nina Raben,Elon Pras,M. Pras,DL Kastner,Trevor Blake,Andreas D. Baxevanis,Christiane M. Robbins,David B. Krizman,Francis S. Collins,Paul P. Liu,Xuejun Chen,M. Shohat,Melanie Hamon,T. L. Kahan,A. Cercek,J. I. Rotter,N. FischelGhodsian,N. Richards,D. A. Shelton,D.L. Gumucio,Y. Yokoyama,Marie Mangelsdorf,A. Orsborn,Robert I. Richards,Darrell O. Ricke,J. M. Buckingham,Robert K. Moyzis,L. L. Deaven,N. A. Doggett +40 more
TL;DR: The cloning of the FMF gene promises to shed light on the regulation of acute inflammatory responses and is described as a member of a family of nuclear factors homologous to the Ro52 autoantigen.
Journal ArticleDOI
Germline mutations in the extracellular domains of the 55 kda tnf receptor, tnfr1, define a family of dominantly inherited autoinflammatory syndromes
Michael F. McDermott,Ivona Aksentijevich,Jérôme Galon,Elizabeth M. McDermott,B. William Ogunkolade,Michael Centola,Elizabeth Mansfield,Massimo Gadina,Leena Karenko,Tom Pettersson,John McCarthy,David M. Frucht,Martin Aringer,Yelizaveta Torosyan,Anna-Maija Teppo,Meredith Wilson,H.Mehmet Karaarslan,Ying Wan,Ian Todd,Geryl Wood,Ryan Schlimgen,Thisum R. Kumarajeewa,Sheldon M. Cooper,John P. Vella,Christopher I. Amos,John C. Mulley,Kathleen A. Quane,Michael G. Molloy,Annamari Ranki,Richard J. Powell,Graham A. Hitman,John J. O'Shea,Daniel L. Kastner +32 more
TL;DR: It is proposed that the autoinflammatory phenotype results from impaired downregulation of membrane TNFR1 and diminished shedding of potentially antagonistic soluble receptor inTNFR1-associated periodic syndromes.
Journal Article
Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium.
Nurit Zaks,James E. Balow,Elizabeth Mansfield,Marie Mangelsdorf,M. Shohat,Trevor Blake,Deborah L. Gumucio,A. Orsborn,Neta Shafran,Andreas D. Baxevanis,CY Yokoyama,S.R.K. Vedula,Francis S. Collins,M. Pras,Geryl Wood,Michael Centola,Zuoming Deng,J. M. Buckingham,Melanie Hamon,Robert K. Moyzis,DL Kastner,N. Richards,Ivona Aksentijevich,Xuejun Chen,C. A. Robbins,Nina Raben,Paul P. Liu,Norman A. Doggett,T. L. Kahan,Robert I. Richards,Elon Pras,Raman Sood,S. Eisenberg +32 more
Journal ArticleDOI
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.
Philip Alex,Nicholas C. Zachos,Thuan Nguyen,Liberty Gonzales,Tian E. Chen,Laurie S. Conklin,Michael Centola,Xuhang Li +7 more
TL;DR: These studies provide insight into disease immunopathogenesis and illustrate the significant potential of utilizing multiplex cytokine profiles and bioinformatics as diagnostic tools in IBD.
Journal ArticleDOI
Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.
Nitza G. Shoham,Michael Centola,Michael Centola,Elizabeth Mansfield,Elizabeth Mansfield,Keith M. Hull,Geryl Wood,Carol Wise,Daniel L. Kastner +8 more
TL;DR: It is shown that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin, which is shown to cause the syndrome of pyogenic arthritis, pyoderma gangrenosum, and acne.