Journal ArticleDOI
Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus
Alim-Louis Benabid,Pierre Pollak,Dominique Hoffmann,C L Gervason,Marc Hommel,Perret J,J. de Rougemont,D.M. Gao +7 more
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TLDR
Reversibility and adaptability, allowing control of side-effects, make thalamic stimulation preferable to thalamotomy, especially when treatment of both sides of the brain is needed.About:
This article is published in The Lancet.The article was published on 1991-02-16. It has received 1725 citations till now. The article focuses on the topics: Essential tremor & Thalamic stimulator.read more
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Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
Patricia Limousin,Paul Krack,Pierre Pollak,Abdelhamid Benazzouz,Claire Ardouin,Dominique Hoffmann,Alim-Louis Benabid +6 more
TL;DR: Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease and the severity of symptoms off medication decreases, and the dose of levodopa can be reduced with consequent reduction in dyskinesias.
Journal ArticleDOI
Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation
Patricia Limousin,Pierre Pollak,Abdelhamid Benazzouz,Dominique Hoffmann,J-F. Le Bas,Perret J,A. L. Benabid,El Broussolle +7 more
TL;DR: The effect of electrical stimulation of the subthalamic nucleus was assessed in three patients with disabling akinetic-rigid Parkinson's disease and severe motor fluctuations and could induce ballism that was stopped by reduction of stimulation.
Journal ArticleDOI
Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders
Alim-Louis Benabid,Pierre Pollak,Dongming Gao,Dominique Hoffmann,Patricia Limousin,Isabelle Payen,A Benazzouz +6 more
TL;DR: Chronic VIM stimulation, which is reversible, adaptable, and well tolerated even by patients undergoing bilateral surgery and by elderly patients, should replace thalamotomy in the regular surgical treatment of parkinsonian and essential tremors.
Journal ArticleDOI
Deep brain stimulation for Parkinson's disease.
TL;DR: Deep brain stimulation at high frequency was first used in 1997 to replace thalamotomy in treating the characteristic tremor of Parkinson’s disease, and has subsequently been applied to the pallidum and the subthalamic nucleus.
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Deep Brain Stimulation
TL;DR: Investigations of the mechanisms of action of DBS have the potential to clarify fundamental issues such as the functional anatomy of selected brain circuits and the relationship between activity in those circuits and behavior.
References
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Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease.
TL;DR: VIM stimulation strongly decreased the tremor but failed to suppress it as completely as thalamotomy did, due in part to the fact that programmable stimulator frequency rate is limited to 130 Hz, while it appeared that the optimal stimulation frequency was 200 Hz.
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The correlation between tremor characteristics and the predicted volume of effective lesions in stereotaxic nucleus ventralis intermedius thalamotomy.
TL;DR: In 51 cases (6 cases with bilateral operations) with various kinds of tremor, stereotaxic ventralis intermedius (Vim) thalamotomies were performed and the results of operation evaluated, the importance of the Vim nucleus in tremor mechanisms is discussed.
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Suppression of intention tremor by contingent deep-brain stimulation
Jason Brice,Lindsay Mclellan +1 more
TL;DR: Severe intention tremor of the upper limb was suppressed in three patients with multiple sclerosis by stimulation in the contralateral midbrain and basal ganglia with stereotactically placed bipolar electrodes.
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Long-term follow-up results of selective VIM-thalamotomy
Yoshishige Nagaseki,Tohru Shibazaki,Tatsuo Hirai,Y. Kawashima,Masafumi Hirato,Hirochiyo Wada,Mizuho Miyazaki,Chihiro Ohye +7 more
TL;DR: It was concluded that radiographically and physiologically monitored selective VIM-thalamotomy for parkinsonian and essential tremor is effective even when lesioning is minimal, and the beneficial effect is maintained over a long period of time.
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What happened to VIM thalamotomy for Parkinson's disease?
TL;DR: VIM thalamotomy remains the treatment of choice for severe drug-resistant parkinsonian tremor and Rigidity and manual dexterity improved less strikingly, the latter only reflecting abolition of tremor; locomotion, speech, facial movement and handwriting did not improve.