Journal ArticleDOI
Deep brain stimulation for Parkinson's disease.
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TLDR
Deep brain stimulation at high frequency was first used in 1997 to replace thalamotomy in treating the characteristic tremor of Parkinson’s disease, and has subsequently been applied to the pallidum and the subthalamic nucleus.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2003-12-01. It has received 989 citations till now. The article focuses on the topics: Deep brain stimulation & Subthalamic nucleus.read more
Citations
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Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism.
TL;DR: It is shown that DBS selectively interferes with the normal ability to slow down when faced with decision conflict, which implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.
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Stem cell therapy for human neurodegenerative disorders-how to make it work.
TL;DR: Findings raise hope for the development of stem cell therapies in human neurodegenerative disorders and need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.
Journal ArticleDOI
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
TL;DR: A review of psychiatric treatments derived from preclinical human and animal studies can be found in this paper, where the authors focus on new rationally designed psychiatric treatments, such as vagal nerve stimulation, rapid transcranial magnetic stimulation and deep brain stimulation, all borrowed from neurological interventions that attempt to target known pathological foci.
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The habenula: from stress evasion to value-based decision-making
TL;DR: The habenula, a highly conserved structure in the brain, provides a fundamental mechanism for both survival and decision-making through its effects on neuromodulator systems, in particular the dopamine and serotonin systems.
References
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Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
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Functional architecture of basal ganglia circuits: neural substrates of parallel processing
TL;DR: Recent evidence indicating that a parallel functional architecture may also be characteristic of the organization within each individual circuit is discussed, which represents a significant departure from earlier concepts of basal ganglia organization.
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Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
TL;DR: The postulated role of excessive activity in the subthalamic nucleus in Parkinson's disease is supported by the effects of lesions evaluated in monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
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Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
Patricia Limousin,Paul Krack,Pierre Pollak,Abdelhamid Benazzouz,Claire Ardouin,Dominique Hoffmann,Alim-Louis Benabid +6 more
TL;DR: Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease and the severity of symptoms off medication decreases, and the dose of levodopa can be reduced with consequent reduction in dyskinesias.
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Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus
Alim-Louis Benabid,Pierre Pollak,Dominique Hoffmann,C L Gervason,Marc Hommel,Perret J,J. de Rougemont,D.M. Gao +7 more
TL;DR: Reversibility and adaptability, allowing control of side-effects, make thalamic stimulation preferable to thalamotomy, especially when treatment of both sides of the brain is needed.