Journal ArticleDOI
Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation
Patricia Limousin,Pierre Pollak,Abdelhamid Benazzouz,Dominique Hoffmann,J-F. Le Bas,Perret J,A. L. Benabid,El Broussolle +7 more
TLDR
The effect of electrical stimulation of the subthalamic nucleus was assessed in three patients with disabling akinetic-rigid Parkinson's disease and severe motor fluctuations and could induce ballism that was stopped by reduction of stimulation.About:
This article is published in The Lancet.The article was published on 1995-01-14. It has received 1285 citations till now. The article focuses on the topics: Subthalamic nucleus.read more
Citations
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Beta-band oscillations--signalling the status quo?
Andreas K. Engel,Pascal Fries +1 more
TL;DR: In this article, the potential functional role of the beta-band oscillations in cognitive processing, on the motor system and on the pathophysiology of movement disorders is discussed. But the authors focus on the maintenance of the current sensorimotor or cognitive state.
Journal Article
Beta-band oscillations--signalling the status quo?
Andreas K. Engel,Pascal Fries +1 more
TL;DR: It is hypothesized that beta oscillations and/or coupling in the beta-band are expressed more strongly if the maintenance of the status quo is intended or predicted, than if a change is expected.
Journal ArticleDOI
Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
Patricia Limousin,Paul Krack,Pierre Pollak,Abdelhamid Benazzouz,Claire Ardouin,Dominique Hoffmann,Alim-Louis Benabid +6 more
TL;DR: Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease and the severity of symptoms off medication decreases, and the dose of levodopa can be reduced with consequent reduction in dyskinesias.
Journal ArticleDOI
The brain basis of emotion: A meta-analytic review
TL;DR: A meta-analytic summary of the neuroimaging literature on human emotion finds little evidence that discrete emotion categories can be consistently and specifically localized to distinct brain regions, and finds evidence that is consistent with a psychological constructionist approach to the mind.
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Optical Deconstruction of Parkinsonian Neural Circuitry
TL;DR: This work used optogenetics and solid-state optics to systematically drive or inhibit an array of distinct circuit elements in freely moving parkinsonian rodents and found that therapeutic effects within the subthalamic nucleus can be accounted for by direct selective stimulation of afferent axons projecting to this region.
References
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Functional architecture of basal ganglia circuits: neural substrates of parallel processing
TL;DR: Recent evidence indicating that a parallel functional architecture may also be characteristic of the organization within each individual circuit is discussed, which represents a significant departure from earlier concepts of basal ganglia organization.
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Primate models of movement disorders of basal ganglia origin
TL;DR: This paper describes the changes in neuronal activity in the motor circuit in animal models of hypo- and hyperkinetic disorders and postulates specific disturbances within the basal ganglia-thalamocortical 'motor' circuit.
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A modified card sorting test sensitive to frontal lobe defects
TL;DR: The usefulness of the MCST for detecting frontal lobe lesions in individual patients was established, and the use of cut-off scores briefly discussed, and a new method of measuring perseverative errors proposed.