Lymphokine inducing "terminal differentiation" of the human monoblast leukemia line U937: a role for gamma interferon.
P. Ralph,P. Ralph,Paul L. Harris,Paul L. Harris,C. J. Punjabi,C. J. Punjabi,K. Welte,K. Welte,P. B. Litcofsky,P. B. Litcofsky,M.-K. Ho,M.-K. Ho,B.Y. Rubin,B.Y. Rubin,M. A. S. Moore,M. A. S. Moore,Timothy A. Springer,Timothy A. Springer +17 more
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TLDR
The Fc-receptor-inducing activity of lymphokine was inhibited by a neutralizing monoclonal antibody to gamma-interferon, suggesting that this differentiation factor in lymphokines is gamma-interspine, which is a differentiation modulator for the monoblast cells.About:
This article is published in Blood.The article was published on 1983-12-01 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Lymphokine & Monoblast.read more
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Human leukemic models of myelomonocytic development: a review of the HL-60 and U937 cell lines.
Paul L. Harris,Peter Ralph +1 more
TL;DR: The human leukemic myeloblast HL‐60 and monoblast U937 cell lines have made important contributions to the disciplines of cancer, hematology, and immunology.
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Role of interferon-gamma in immune cell regulation
Howard A. Young,Kenneth J. Hardy +1 more
TL;DR: The effects of IFN‐γ on the various cell lineages of the immune system, focusing on the biology of its actions are discussed, and research focused on the consequences of introducing IFN'γ cDNA into tumor cells, aberrant IFN•γ production in transgenic animals, and inhibition of IFn‐γ effects are summarized.
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Oligospecificity of the Cellular Adhesion Receptor MAC-1 Encompasses an Inducible Recognition Specificity for Fibrinogen
TL;DR: Evidence is presented here that the leukocyte adhesion receptor Mac-1 can be specifically induced to bind fibrinogen with characteristics immunochemically and functionally distinct from the established Arg-Gly- Asp-directed fibr inogen receptors.
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Purification of a factor inducing differentiation of mouse myeloid leukemic M1 cells from conditioned medium of mouse fibroblast L929 cells.
TL;DR: The purified factor gave a single band of protein with a molecular weight of 62,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis which coincided with biological activity, suggesting that it was distinct from the growth factor for normal precursors of macrophages and/or granulocytes.
Journal Article
Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation.
TL;DR: The regulation of Mac- 1, LFA-1, and p150,95 expression during leukocyte differentiation was examined and resembled hairy cell leukemia, a B cell plasmacytoid leukemia.
References
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Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)
TL;DR: The histiocytic origin of the cell line was shown by its capacity for lysozyme production and the strong esterase activity of the cells, and it was concluded that the U‐937 is a neoplastic, histuocytic cell line.
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Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.
TL;DR: The results show that Mac-1 is either identical to CR3 or closely associated with CR3 function, one of the first cases in which a monoclonal antibody-defined differentiation antigen has been associated with a specific cell surface function.
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Expression of myeloid differentiation antigens on normal and malignant myeloid cells.
TL;DR: A series of monoclonal antibodies have been characterized that define four surface antigens (MY3, MY4, MY7, and MY8) of human myeloid cells derived from a fusion of the NS-1 plasmacytoma cell line with splenocytes from a mouse immunized with human acute myelomonocytic leukemia cells.
Journal Article
Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells.
TL;DR: The results demonstrate that the effects ofHuIFN gamma and HuIFN alpha are due to the HuIFn themselves and that these actions on the hematopoietic progenitor cells are probably not mediated through monocytes and/or lymphocytes.
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Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines.
TL;DR: Among murine cell lines, lysozyme was produced by three histiocytic lymphoma or macrophage lines, which mediate antibody- dependent phagocytosis and cytolysis, and a spontaneous lymphoma and an Abelson leukemia virus-induced lymphoma.