Journal ArticleDOI
Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study.
Hossein Ardeschir Ghofrani,Hossein Ardeschir Ghofrani,Gérald Simonneau,Gérald Simonneau,Andrea Maria D'Armini,Peter F. Fedullo,Luke Howard,Luke Howard,Xavier Jaïs,Xavier Jaïs,David P. Jenkins,Zhi-Cheng Jing,Michael M. Madani,Nicolas Martin,Eckhard Mayer,Kelly Papadakis,Dominik Richard,Nick H. Kim,Irene Lang,Christian M. Kähler,Marion Delcroix,Zoheir Bshouty,Pablo Sepulveda Varela,Yuanhua Yang,Jin-Ming Liu,Gang-Cheng Zhang,Nuofu Zhang,Yuhong Mi,Xian-Yang Zhu,Pavel Jansa,Grégoire Prévot,Hélène Bouvaist,Olivier Sanchez,Friedrich Grimminger,Matthias Held,Heinrike Wilkens,Stephan Rosenkranz,Ekkehard Grünig,Kristóf Karlócai,András Temesvári,Istvan Edes,Sigita Aidietienė,Skaidrius Miliauskas,Tomas Rene Pulido Zamudio,Carlos Jerjes Sanchez,Anton Vonk Noordegraaf,Jerzy Lewczuk,Piotr Podolec,Jarosław Kasprzak,Tatiana Mularek-Kubzdela,Ryszard Grzywna,Keertan Dheda,Olga Moiseeva,Alexander Chernyavskiy,Vladimir M. Shipulin,Olga Barbarash,Tamila Vitalievna Martynyuk,Hyung Kwan Kim,Jun Bean Park,Jae Seung Lee,Rudolf Speich,Silvia Ulrich,John-David Aubert,Arintaya Phrommintikul,Nattapong Jaimchariyatam,Suree Sompradeekul,Zeynep Pinar Onen,Gulfer Okumus,Lyubomyr Solovey,Volodymyr Gavrysyuk,Luke S. Howard,Joanna Pepke-Zaba,Robin Condliffe,John McConnell,Kim M. Kerr,Lan Hieu Nguyen,Nguyen Vinh Pham +76 more
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TLDR
In MERIT-1, macitentan significantly improved PVR in patients with inoperable CTEPH and was well tolerated, and resting PVR at week 16, expressed as percentage of PVR measured at baseline.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-10-01. It has received 189 citations till now. The article focuses on the topics: Macitentan & Placebo-controlled study.read more
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Journal ArticleDOI
Advances in targeted therapy for chronic thromboembolic pulmonary hypertension.
TL;DR: The achievements and unresolved problems of PAH-targeted therapy for CTEPH over the last decade are summarized.
Journal ArticleDOI
Chronic Thromboembolic Disease and Chronic Thromboembolic Pulmonary Hypertension
Irene M. Lang,Ioana A Campean,Roela Sadushi-Kolici,R Badr-Eslam,Christian Gerges,Nika Skoro-Sajer +5 more
TL;DR: Chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thrombolic pulmonary vascular disease (CTED) are rare manifestations of venous thrombinopathy as discussed by the authors.
Journal ArticleDOI
Chronic Thromboembolic Pulmonary Hypertension-Management Strategies and Outcomes.
Sagar Ranka,Divyanshu Mohananey,Nikhil Agarwal,Beni R Verma,Pedro A. Villablanca,Holly E.M. Mewhort,Harish Ramakrishna +6 more
TL;DR: D diagnosis remains challenging given the lack of early clinical signs and overlap with other cardiopulmonary conditions, but use of riociguat has shown promising improvements in functional outcomes up to 2 years after initiation.
Journal ArticleDOI
Chronic Thromboembolic Pulmonary Hypertension: An Update
Barbara Ruaro,Elisa Baratella,G. Caforio,Paola Confalonieri,Barbara Wade,Cristina Marrocchio,Pietro Geri,R. Pozzan,Alessia Giovanna Andrisano,Maria Assunta Cova,Maurizio Cortale,Marco Confalonieri,Francesco Salton +12 more
TL;DR: Pulmonary endarterectomy (PEA) reduces pulmonary vascular resistance, making it the treatment of choice and should be offered to operable CTEPH patients, as significant symptomatic and prognostic improvement has been observed.
Journal ArticleDOI
Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going
TL;DR: The present uses of endothelin receptor antagonists and the advancements in the development of future treatment options are highlighted, thereby providing an overview ofendothelin research over the years and its future scope.
References
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Journal ArticleDOI
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Nazzareno Galiè,Marc Humbert,Jean-Luc Vachiery,Simon Gibbs,Irene Lang,Adam Torbicki,Gérald Simonneau,Andrew Peacock,Anton Vonk Noordegraaf,Maurice Beghetti,Ardeschir Ghofrani,Miguel Angel Gomez Sanchez,Georg Hansmann,Walter Klepetko,Patrizio Lancellotti,Marco Matucci,Theresa McDonagh,Luc Pierard,Pedro T. Trindade,Maurizio Zompatori,Marius M. Hoeper +20 more
TL;DR: In this paper, the authors defined the following terms: ALAT, alanine aminotransferase, ASAT, aspartate AMINOTE, and APAH, associated pulmonary arterial hypertension.
Journal ArticleDOI
Special article2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension
Nazzareno Galiè,Marc Humbert,Jean-Luc Vachiery,Simon Gibbs,Irene Lang,Adam Torbicki,Gérald Simonneau,Andrew J. Peacock,Anton Vonk Noordegraaf,Maurice Beghetti,Ardeschir Ghofrani,Miguel Angel Gomez Sanchez,Georg Hansmann,Walter Klepetko,Patrizio Lancellotti,Marco Matucci,Theresa McDonagh,Luc Pierard,Marius M. Hoeper +18 more
TL;DR: This article is being published concurrently in the European Heart Journal and the European Respiratory Journal and is identical except for minor stylistic and spelling differences in keeping with each journal’s style.
Journal ArticleDOI
Inhaled iloprost for severe pulmonary hypertension.
Horst Olschewski,Gérald Simonneau,Nazzareno Galiè,T. Higenbottam,Robert Naeije,Lewis J. Rubin,Sylvia Nikkho,Rudolf Speich,Marius M. Hoeper,Jürgen Behr,Jörg Winkler,Olivier Sitbon,Wladimir Popov,H. Ardeschir Ghofrani,Alessandra Manes,David G. Kiely,R Ewert,Andreas Meyer,Paul A. Corris,Marion Delcroix,Miguel Ángel Gómez-Sánchez,Harald Siedentop,Werner Seeger +22 more
TL;DR: Inhaled Iloprost is an effective therapy for patients with severe pulmonary hypertension and hemodynamic values were significantly improved at 12 weeks when measured after iloprost inhalation, and were significantly worse in the placebo group.
Journal ArticleDOI
Macitentan and morbidity and mortality in pulmonary arterial hypertension.
Tomás Pulido,Igor Adzerikho,Richard N. Channick,Marion Delcroix,Nazzareno Galiè,Hossein Ardeschir Ghofrani,Pavel Jansa,Zhi-Cheng Jing,Franck-Olivier Le Brun,Sanjay Mehta,Camilla Mittelholzer,Loïc Perchenet,B.K.S. Sastry,Olivier Sitbon,Rogério Souza,Adam Torbicki,Xiaofeng Zeng,Lewis J. Rubin,Gérald Simonneau +18 more
TL;DR: Macitentan significantly reduced morbidity and mortality among patients with pulmonary arterial hypertension in this event-driven study.
Journal ArticleDOI
Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension
Hossein Ardeschir Ghofrani,Andrea Maria D'Armini,Friedrich Grimminger,Marius M. Hoeper,Pavel Jansa,Nick H. Kim,Eckhard Mayer,Gérald Simonneau,Martin R. Wilkins,Arno Fritsch,Dieter Neuser,Gerrit Weimann,Chen Wang +12 more
TL;DR: Riociguat significantly improved exercise capacity and pulmonary vascular resistance in patients with chronic thromboembolic pulmonary hypertension.
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2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Nazzareno Galiè,Marc Humbert,Jean-Luc Vachiery,Simon Gibbs,Irene Lang,Adam Torbicki,Gérald Simonneau,Andrew Peacock,Anton Vonk Noordegraaf,Maurice Beghetti,Ardeschir Ghofrani,Miguel Angel Gomez Sanchez,Georg Hansmann,Walter Klepetko,Patrizio Lancellotti,Marco Matucci,Theresa McDonagh,Luc Pierard,Pedro T. Trindade,Maurizio Zompatori,Marius M. Hoeper +20 more
Long-Term Outcome of Patients With Chronic Thromboembolic Pulmonary Hypertension: Results From an International Prospective Registry.
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Joanna Pepke-Zaba,Marion Delcroix,Irene Lang,Eckhard Mayer,Pavel Jansa,David Ambroz,Carmen M. Treacy,Andrea Maria D'Armini,Marco Morsolini,Repke J. Snijder,Paul Bresser,Adam Torbicki,Bent Bruun Kristensen,Jerzy Lewczuk,Iveta Simkova,Joan Albert Barberà,Marc de Perrot,Marius M. Hoeper,Sean Gaine,Rudolf Speich,Miguel Ángel Gómez-Sánchez,Gabor Kovacs,A. Hamid,Xavier Jaïs,Gérald Simonneau +24 more