Patent
Macrophage migration inhibitory factor (MIF) promoter polymorphism in inflammatory disease
John A. Baugh,Richard Bucala,Smita Chitnis,Donnelly Seamus C,Peter K. Gregersen,Joanita Monteiro +5 more
TLDR
In this paper, a novel CATT-tetranucleotide repeat polymorphism at position -817 of the human Mif gene that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays was described.Abstract:
Describe herein is a novel CATT-tetranucleotide repeat polymorphism at position -817 of the human Mif gene that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-CATT repeat units. Of these, the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients. Methods, compositions and apparatus for detecting this CATT-tetranucleotide repeat polymorphism at position -817 of the human Mif gene, and for using same for assessing predisposition to severe inflammatory disease, are also disclosed.read more
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Patent
Oxmif as a diagnostic marker
TL;DR: In this article, the recognition that a specific oxMIF form of MIF is useful as a diagnostic marker in (MIF-related) diseases, in particular for example monitoring of disease progression.
Patent
Polymorphisms in nod2/card15 gene
TL;DR: The NOD2/CARD15 gene polymorphism was first identified by as discussed by the authors, who found that at least one of the Nod2-SNP8, Nod 2-NSNP12, and Nod 3-NPSP13 polymorphisms in the NOD 2/NSP15 gene can be linked to at least three diseases.
Patent
Mif agonists and antagonists and therapeutic uses thereof
TL;DR: In this paper, the authors present methods and compositions for selecting a subject for treatment with an agonist or antagonist of macrophage migration inhibitory factor (MIF), identifying a subject at risk for developing a disease associated with high or low MIF expression, predicting the severity of a disease in a subject, and predicting whether a subject is susceptible to a disease.
Patent
Combination therapy of anti-mif antibodies and glucocorticoids
TL;DR: In this article, anti-MIF antibodies were used in combination with glucocorticoids in the treatment of glycocortia receptive diseases, and the results showed promising results.
Patent
Compositions and methods for the modulation of detrusor activity
George A. Kuchel,Richard Bucala +1 more
TL;DR: In this paper, a method for diagnosing bladder disease and/or severity comprising screening for a MIF gene or MIF receptor gene polymporhism or expression level.
References
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Journal ArticleDOI
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
Marc Feldmann,Ravinder N. Maini +1 more
TL;DR: Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab, a chimeric anti-TNF alpha monoclonal antibody (mAB), has provided evidence that TNF regulates IL-6, IL-8, MCP-1, and VEGF production, recruitment of immune and inflammatory cells into joints, angiogenesis, and reduction of blood levels of matrix metalloproteinases-1 and -3.
Journal ArticleDOI
Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.
TL;DR: It is demonstrated that, following incubation of sensitive lymphoid cells with specific antigen for 24 hr, a nondialyzable substance is detected in the cell-free supernatants which inhibits the migration of normal peritoneal cells.
Journal ArticleDOI
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.
William McGuire,Adrian V. S. Hill,Catherine E. M. Allsopp,Brian Greenwood,Dominic P. Kwiatkowski +4 more
TL;DR: The maintenance of the TNF2 allele at a gene frequency of 0.16 in The Gambia implies that the increased risk of cerebral malaria in homozygotes is counterbalanced by some biological advantage, suggesting that regulatory polymorphisms of cytokine genes can affect the outcome of severe infection.
Journal ArticleDOI
MIF as a glucocorticoid-induced modulator of cytokine production
Thierry Calandra,Jürgen Bernhagen,Christine N. Metz,Lori Spiegel,Michael Bacher,Thomas M. Donnelly,Anthony Cerami,Richard Bucala +7 more
TL;DR: The unexpected finding that low con-centrations of glucocorticoids induce rather than inhibit MIF production from macrophages is reported, identifying a unique counter-regulatory system that functions to control inflammatory and immune responses.
Journal ArticleDOI
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
Jürgen Bernhagen,Thierry Calandra,Robert A. Mitchell,S. B. Martin,Kevin J. Tracey,Wolfgang Voelter,Kirk R. Manogue,A. Cerami,Richard Bucala +8 more
TL;DR: Macrophage migration inhibitory factor (MIF) is identified as a major secreted protein released by anterior pituitary cells in response to LPS stimulation, and it is concluded that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock.