Open Access
Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
About:
The article was published on 1979-01-01 and is currently open access. It has received 210 citations till now. The article focuses on the topics: Locus (genetics) & Visceral leishmaniasis.read more
Citations
More filters
Journal ArticleDOI
The immunogenetics of human infectious diseases
TL;DR: It is likely that susceptibility to most microorganisms is determined by a large number of polymorphic genes, and identification of these should provide insights into protective and pathogenic mechanisms in infectious diseases.
Book ChapterDOI
Immunology of Leishmaniasis
F.Y. Liew,Catherine A. O'Donnell +1 more
TL;DR: The role of the immune response to Leishmania, with particular reference to the cutaneous disease caused by L. major, is discussed, and the concept of suppressor T cells is reviewed.
Book ChapterDOI
Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans.
TL;DR: The review aims to put current knowledge of Leishmania and the leishmaniases in perspective and to underline priority questions which 'leishmaniacs' must answer in various domains: epidemiology, population genetics, taxonomy and pathogenicity.
Journal ArticleDOI
Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease
TL;DR: Different virulence factors have been identified for distinct Leishmania species, and there are profound differences in the immune mechanisms that mediate susceptibility/resistance to infection and in the pathology associated with disease.
Journal ArticleDOI
Immunopathogenesis of infection with the visceralizing Leishmania species.
TL;DR: This review focuses on host responses to infection with the species that cause visceral leishmaniasis, as they contrast with species causing localized cutaneous leish maniasis, which includes asymptomatic self-resolving infection, localized skin lesions, and progressive visceral leishingmaniasis.
References
More filters
Journal ArticleDOI
The mouse liver aldehyde oxidase locus (Aox).
TL;DR: Aldehyde oxidase activity was shown to be independent of adrenal influence and to have no clear-cut survival value for animals treated with large doses of N1-methylnicotinamide and the following gene order was deduced: Aox-Id-1-Dip-1.