Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures
Zhi-Hui Meng,Tian-Tian Sun,Guo-Zheng Zhao,Yu-Fei Yue,Qing-Hua Chang,Hua-Jie Zhu,Fei Cao +6 more
- Vol. 3, Iss: 1, pp 44-61
TLDR
A comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019, is presented in this article.Abstract:
Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982–2019.read more
Citations
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Marine natural products.
TL;DR: In this paper , a review of the literature published in 2019 for marine natural products (MNPs) with 736 citations (724 for the period January to December 2021) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Marine natural products.
TL;DR: A review of the literature published in 2020 for marine natural products (MNPs), with 757 citations (747 for the period January to December 2020) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms as discussed by the authors .
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Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities.
TL;DR: The marine environment is an underexplored treasure that hosts huge biodiversity of microorganisms as mentioned in this paper, and marine-associated Cladosporium species have attracted considerable interest because of their ability to produce a wide array of metabolites, including alkaloids, macrolides, diketopiperazines, pyrones, tetralones, sterols, phenolics, terpenes, lactones, and tetramic acid derivatives.
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Structural Simplification of Marine Natural Products: Discovery of Hamacanthin Derivatives Containing Indole and Piperazinone as Novel Antiviral and Anti-phytopathogenic-fungus Agents.
TL;DR: In this paper, a series of hamacanthin derivatives were designed, synthesized, and studied on the antiviral and antifungal activities, and the results showed that compound 13h could bind to TMVCP and interfere with the assembly process of TMV CP and RNA.
Journal ArticleDOI
The role of bacterial signaling networks in antibiotics response and resistance regulation
Yuying Li,Tao Feng,Yan Wang +2 more
TL;DR: In this article , the authors provide an overview of how bacterial intraspecific and interspecific signaling networks affect the response to environmental antibiotics and provide theoretical support for inhibiting bacterial antibiotic resistance and alleviating health and ecological problems caused by antibiotic contamination.
References
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Marine indole alkaloids: potential new drug leads for the control of depression and anxiety
TL;DR: Information is provided on current and potential pharmaceuticals including small molecule natural indole alkaloids to their biological properties, structure-activity relationship studies, and especially their potential for the treatment of neurological disorders, including depression.
Journal ArticleDOI
Drug development from marine natural products
Tadeusz F. Molinski,Doralyn S. Dalisay,Sarah L. Lievens,Sarah L. Lievens,Jonel P. Saludes,Jonel P. Saludes +5 more
TL;DR: The history of drug discovery from marine natural products is reviewed, and by describing selected examples, the factors that contribute to new discoveries and the difficulties associated with translating marine-derived compounds into clinical trials are examined.
Journal ArticleDOI
Secondary metabolites of fungi from marine habitats.
TL;DR: An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.
Journal ArticleDOI
Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
Waseem Gul,Mark T. Hamann +1 more
TL;DR: Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism and other pharmacological activities.
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Notoamides A–D: Prenylated Indole Alkaloids Isolated from a Marine‐Derived Fungus, Aspergillus sp.
Hikaru Kato,Takushi Yoshida,Takanori Tokue,Yuka Nojiri,Hiroshi Hirota,Tomihisa Ohta,Robert M. Williams,Robert M. Williams,Sachiko Tsukamoto +8 more
TL;DR: Six new prenylated indole alkaloids, named notoamides F−K (8−13), were isolated from a marine-derived Aspergillus sp.