Journal ArticleDOI
Mast-cell responses to pathogens
TLDR
Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated.Abstract:
Mast cells have mainly been studied in the setting of allergic disease, but the importance of mast cells for host defence against several pathogens has now been well established. The location of mast cells, which are found closely associated with blood vessels, allows them to have a crucial sentinel role in host defence. The mast cell has a unique 'armamentarium' of receptor systems and mediators for responding to pathogen-associated signals. Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated.read more
Citations
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Journal ArticleDOI
The development of allergic inflammation
TL;DR: It is important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reaction.
Journal ArticleDOI
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
TL;DR: This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.
Journal ArticleDOI
Mast cells in the development of adaptive immune responses
TL;DR: Mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings.
Journal ArticleDOI
Integrated signalling pathways for mast-cell activation
TL;DR: How the capacity of KIT, and other receptors, to influence FcεRI-dependent mast-cell-mediator release might be a function of the relative abilities of these receptors to activate these alternative pathways is described.
Journal ArticleDOI
Mast cell secretory granules: armed for battle
Sara Wernersson,Gunnar Pejler +1 more
TL;DR: The current knowledge of mast cell secretory granules is discussed, which shows that mast cell granule proteases account for many of the protective and detrimental effects of mast cells in various inflammatory settings.
References
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Journal ArticleDOI
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten J. Kirschning,Shizuo Akira,Grayson B. Lipford,Hermann Wagner,Stefan Bauer +8 more
TL;DR: It is shown that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus–1 (HIV-1) stimulate dendritic cells and macrophages to secrete interferon-α and proinflammatory, as well as regulatory, cytokines, and these data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8.
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Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.
Marshall Plaut,Jacalyn H. Pierce,Cynthia J. Watson,J. Hanley-Hyde,Richard P. Nordan,William E. Paul +5 more
TL;DR: It is shown that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells).
Journal ArticleDOI
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
TL;DR: It is reported here that mast cells, which are selectively located at portals of bacterial entry, are important to host defence against bacterial infections.
Journal ArticleDOI
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
Lisa M. Coussens,Wilfred W. Raymond,Gabriele Bergers,Marion Laig-Webster,Ole Behrendtsen,Zena Werb,George H. Caughey,Douglas Hanahan +7 more
TL;DR: Regulation of angiogenesis during squamous carcinogenesis is biphasic: in hyperplasias, dysplasia, and invading cancer fronts, inflammatory mast cells are conscripted to reorganize stromal architecture and hyperactivate angiynthesis; within the cancer core, upregulation ofAngiogenesis factors in tumor cells apparently renders them self-sufficient at sustaining neovascularization.
Journal ArticleDOI
Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin
John R. Gordon,Stephen J. Galli +1 more
TL;DR: Evidence is presented that resident mouse peritoneal mast cells constitutively contain large amounts of TNF-α bioactivity, whereas cultured, immature mast cells vary in their T NF-α content, and that release of TTF-α by mast cells may contribute to host defence, the pathophysiology of allergic diseases and other processes dependent on TFB.