Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).
TLDR
Mastoparan displays a novel mode of toxicity by acting directly on G proteins to mimic the role normally played by agonist-liganded receptors.About:
This article is published in Journal of Biological Chemistry.The article was published on 1988-05-15 and is currently open access. It has received 674 citations till now. The article focuses on the topics: Mastoparan & G protein.read more
Citations
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Book ChapterDOI
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
TL;DR: In this paper, the authors focused on interleukin-8 (IL-8) and related chemotactic cytokines, namely, CXC and CC chemokines.
Journal ArticleDOI
Sequence alignment of the G-protein coupled receptor superfamily.
TL;DR: This work has compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.
Journal ArticleDOI
G Protein-Coupled Receptor Allosterism and Complexing
TL;DR: It is proposed that the study of allosteric phenomena will become of progressively greater import to the drug discovery process due to the advent of newer and more sensitive GPCR screening technologies.
Journal ArticleDOI
Association of a human G-protein β3 subunit variant with hypertension
Winfried Siffert,Dieter Rosskopf,G. Siffert,S Busch,A Moritz,Raimund Erbel,A M Sharma,Eberhard Ritz,H E Wichmann,Karl Jakobs,Bernhard Horsthemke +10 more
TL;DR: A novel polymorphism (C825T) in exon 10 of the gene encoding the p3 subunit of heterotrimeric G proteins (GNB3) is detected, which suggests a significant association of the T allele with essential hypertension.
Journal ArticleDOI
Cell penetration by transportan
TL;DR: The cell-penetrating ability of transportan is not restricted by cell type, but seems to be a general feature of this peptide.
References
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Journal ArticleDOI
G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain
TL;DR: The alpha subunit of GO was isolated without the use of ligands known to dissociate other G proteins, and should be of great utility in elucidating the mechanism of action of this family of GTP-binding proteins.
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A family of receptors coupled to guanine nucleotide regulatory proteins.
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Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes.
TL;DR: It is found that light induces profound changes in the interaction of rhodopsin kinase11, GTPase, and other proteins with the photoreceptor membrane that are reversible in the dark, are strongly influenced by GTP, and are thought to be involved in the regulation of enzyme activity by light.
Journal ArticleDOI
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.
TL;DR: The physical characteristics of Gi are important determinants of its role as the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.