Journal ArticleDOI
Sequence alignment of the G-protein coupled receptor superfamily.
TLDR
This work has compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.Abstract:
The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for understanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.read more
Citations
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Journal ArticleDOI
Dopamine Receptors: From Structure to Function
TL;DR: Target deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions and provide unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disorders.
Journal ArticleDOI
Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
Journal ArticleDOI
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
Book ChapterDOI
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
TL;DR: In this paper, the authors focused on interleukin-8 (IL-8) and related chemotactic cytokines, namely, CXC and CC chemokines.
Journal ArticleDOI
The cloning of a family of genes that encode the melanocortin receptors
TL;DR: The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned and define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.
References
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Journal ArticleDOI
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
TL;DR: The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.
Journal ArticleDOI
Assembly of asparagine-linked oligosaccharides.
TL;DR: The structure of ASPARAGINE-LINKed OLIGOSACCI-IARIDES and transfer-Oligosaccharide Structural Requirements, and Sequence of Processing and Specificity of Processing Enzymes are presented.
Journal ArticleDOI
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
Journal ArticleDOI
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
TL;DR: A novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor is revealed.
Journal ArticleDOI
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.
TL;DR: A complete atomic model for bacteriorhodopsin between amino acid residues 8 and 225 has been built and suggests that pK changes in the Schiff base must act as the means by which light energy is converted into proton pumping pressure in the channel.