Journal ArticleDOI
Measurements of tumor vascular leakiness using DCE in brain tumors: clinical applications
TLDR
The purpose of this article is to discuss the clinical applications of available imaging techniques, and in particular dynamic contrast‐enhanced T1‐weighted MR imaging (DCE‐MRI), to evaluate tumor vascular leakiness.Abstract:
Various imaging techniques have been employed to evaluate blood–brain-barrier leakiness in brain tumors, as higher tumor vascular leakiness is known to be associated with higher grade and malignant potential of the tumor, and hence can help provide additional diagnostic and prognostic information. These imaging techniques range from routine post-contrast T1-weighted images that highlight degree of contrast enhancement to absolute measurement of quantitative metrics of vascular leakiness employing complex pharmacokinetic modeling. The purpose of this article is to discuss the clinical applications of available imaging techniques, and in particular dynamic contrast-enhanced T1-weighted MR imaging (DCE-MRI), to evaluate tumor vascular leakiness. Copyright © 2013 John Wiley & Sons, Ltd.read more
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Rethinking cancer nanotheranostics.
TL;DR: The evolution and state of the art of cancer nanotheranostics is described, with an emphasis on clinical impact and translation, and how diagnosis and therapy are interwoven to solve clinical issues and improve treatment outcomes.
Journal ArticleDOI
Assessment of blood–brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review
Anna K. Heye,Ross D. Culling,Maria del C. Valdés Hernández,Michael J. Thrippleton,Joanna M. Wardlaw +4 more
TL;DR: DCE-MRI is shown to provide valuable information in a large variety of applications, ranging from common applications, such as grading of primary brain tumors, to more recent applications,such as assessment of subtle BBB dysfunction in Alzheimer's disease.
Journal ArticleDOI
Current Clinical Brain Tumor Imaging.
TL;DR: An overview of current magnetic resonance imaging methods routinely employed in the care of the brain tumor patient focuses on advanced techniques including diffusion, perfusion, spectroscopy, tractography, and functional MRI as they pertain to noninvasive characterization of brain tumors and pretreatment evaluation.
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Glioma grading by microvascular permeability parameters derived from dynamic contrast-enhanced MRI and intratumoral susceptibility signal on susceptibility weighted imaging
TL;DR: Volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and the degree of ITSS in glioma grading were assessed, revealing associations between Ktrans, Ve, ITSS, and tumor grade.
Journal ArticleDOI
Clinical Applications of Contrast-Enhanced Perfusion MRI Techniques in Gliomas: Recent Advances and Current Challenges.
TL;DR: The status of glioma theranostics and tumor-associated vascular pathology is outlined and an overview of the principles of dynamic contrast-enhanced MRI (DCE-MRI) and dynamic susceptibility contrast-MRI (DSC-MRI), with emphasis on their recent clinical applications in gliomas are presented.
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Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts.
Paul S. Tofts,Allan G. Kermode +1 more
TL;DR: Leakage of Gd‐DTPA through a defective blood‐brain barrier is measured quantitatively using dynamic MRI scanning, in which repeated scans are made after a bolus injection, and implies permeability in the range 4‐17 × 10−6 cm s−1, in broad agreement with other physiological methods.
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