Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation
Reads0
Chats0
TLDR
This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.Abstract:
Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. This metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to non-alcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, finally, hepatocellular carcinomas. The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Significant involvement of pro-inflammatory cytokines-including interleukin (IL)-1β, IL-6 and tumour necrosis factor-α-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.read more
Citations
More filters
Journal Article
Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
TL;DR: The interaction between diabetes, oxidative stress and inflammation, factors promoting prevalence of diabetes mellitus, mechanisms involved in hyperglycaemia-induced oxidative stress with particular focus on type 2 diabetes and selected diabetic complications are examined.
Journal ArticleDOI
Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes
Li Tang,Li Tang,Yuanyuan Wu,Mi Tian,C. David Sjöström,Ulrika Johansson,Xiao-Rong Peng,David M. Smith,Yufeng Huang +8 more
TL;DR: It is demonstrated that dapagliflozin not only improves hyperglycemia but also slows the progression of diabetes-associated glomerulosclerosis and liver fibrosis by improving hyper glycemia-induced tissue inflammation and oxidative stress.
Journal ArticleDOI
Dacryodes edulis enhances antioxidant activities, suppresses DNA fragmentation in oxidative pancreatic and hepatic injuries; and inhibits carbohydrate digestive enzymes linked to type 2 diabetes.
Ochuko L. Erukainure,Ramgopal Mopuri,Olajumoke A. Oyebode,Neil A. Koorbanally,Md. Shahidul Islam +4 more
TL;DR: Results indicate the anti-oxidative, anti-diabetic and anti-obesogenic potentials of D. edulis leaves, which gives credence to its antidiabetic folkloric claims.
Journal ArticleDOI
Review article: drug‐induced liver injury in the context of nonalcoholic fatty liver disease – a physiopathological and clinical integrated view
TL;DR: Nonalcoholic fatty disease is the most common liver disease, since it is strongly associated with obesity and metabolic syndrome pandemics, and drugs may trigger fatty liver and inflammation per se by mimicking NAFLD pathophysiological mechanisms.
Journal ArticleDOI
The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies
Rafaella Araujo Gonçalves,Rafaella Araujo Gonçalves,Nadeeja Wijesekara,Paul E. Fraser,Fernanda G. De Felice,Fernanda G. De Felice +5 more
TL;DR: The deleterious consequences of Tau pathology-induced insulin resistance to the brain and/or peripheral tissues are highlighted, suggesting that these are key events mediating cognitive decline in Alzheimer’s disease (AD) and other tauopathies.
References
More filters
Journal ArticleDOI
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
Goodarz Danaei,Mariel M. Finucane,Yuan Lu,Gitanjali M Singh,Melanie J. Cowan,Christopher J. Paciorek,Christopher J. Paciorek,John K Lin,Farshad Farzadfar,Young-Ho Khang,Gretchen A Stevens,Mayuree Rao,Mohammed K. Ali,Leanne M Riley,Carolyn Robinson,Majid Ezzati +15 more
TL;DR: Glycaemia and diabetes are rising globally, driven both by population growth and ageing and by increasing age-specific prevalences, and effective preventive interventions are needed, and health systems should prepare to detect and manage diabetes and its sequelae.
Journal ArticleDOI
Diabetes, oxidative stress, and antioxidants: a review
TL;DR: There is a need to continue to explore the relationship between free radicals, diabetes, and its complications, and to elucidate the mechanisms by which increased oxidative stress accelerates the development of diabetic complications, in an effort to expand treatment options.
Journal ArticleDOI
Human fatty liver disease: old questions and new insights.
TL;DR: Recent mechanistic insights into nonalcoholic fatty liver disease are discussed, focusing primarily on those that have emerged from human genetic and metabolic studies.
Journal ArticleDOI
Advanced glycation endproducts—role in pathology of diabetic complications
TL;DR: The chemistry of glycation and AGEs is introduced and the mechanisms by which they mediate their toxicity are examined and the role of A GEs in the pathogenesis of retinopathy, cataract, atherosclerosis, neuropathy, nephropathy, diabetic embryopathy and impaired wound healing are considered.