Medicinal chemistry of acridine and its analogues.
Parteek Prasher,Mousmee Sharma +1 more
TLDR
In this review, a detailed picture covering the important therapeutic aspects of the acridone nucleus and its functional analogues is discussed.Abstract:
'Acridine' along with its functional analogue 'Acridone' is the most privileged pharmacophore in medicinal chemistry with diverse applications ranging from DNA intercalators, endonuclease mimics, ratiometric selective ion sensors, and P-glycoprotein inhibitors in countering the multi-drug resistance, enzyme inhibitors, and reversals of neurodegenerative disorders. Their interaction with DNA and ability of selectively identifying numerous biologically useful ions has cemented exploitability of the acridone nucleus in modern day therapeutics. Additionally, most derivatives and salts of acridine are planar, crystalline, and stable displaying a strong fluorescence which, when coupled with their marked bio selectivity and low cytotoxicity, enables the studying and monitoring of several biochemical, metabolic, and pharmacological processes. In this review, a detailed picture covering the important therapeutic aspects of the acridone nucleus and its functional analogues is discussed.read more
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Silver nanoparticles as antimicrobial therapeutics: current perspectives and future challenges
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Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review.
TL;DR: 1,2,3-1H-Triazole nucleus, being a planar and biologically acceptable scaffold, plays a crucial role in the design of biomolecular mimetics and tailor-made molecules with therapeutic relevance, and forms an integral part of the current fragment-based approaches for drug design, kinetic target guided synthesis and bioorthogonal methodologies.
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Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets.
TL;DR: In this article, a review of quinoline compounds acting with classical/well-known mechanisms of action (DNA intercalators or Topoisomerase inhibitors) is presented, focusing on compounds interfering with DNA structure or with proteins/enzymes involved in the regulation of double helix functional processes.
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Acetylcholinesterase inhibitors for the treatment of Alzheimer's disease - a patent review (2016-present).
Martina Bortolami,Daniele Rocco,Antonella Messore,Roberto Di Santo,Roberta Costi,Valentina Noemi Madia,Luigi Scipione,Fabiana Pandolfi +7 more
TL;DR: In this article, the authors analyzed the patents from 2016 to present regarding the use of AChEIs in AD, and found that the research on new combinations of existing drugs, with known pharmacodynamic and ADME profile, could shorten the time and reduce the costs to develop a new therapeutic treatment for AD, which is reflected in the research programs that are oriented toward the development of new therapeutics able to operate on multiple targets involved in the disease progression.
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Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System.
Garima Shrivastava,Hamid A. Bakshi,Alaa A. A. Aljabali,Vijay Mishra,Faruck Lukmanul Hakkim,Nitin Charbe,Prashant Kesharwani,Dinesh Kumar Chellappan,Kamal Dua,Murtaza M. Tambuwala +9 more
TL;DR: This review epigrammatically highlights the significance of targeted drug delivery and presents a comprehensive description of the principle barriers faced by nucleus targeted drug Delivery paradigm and ensuing complexities thereof.
References
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Book
Principles of Nucleic Acid Structure
TL;DR: The goal of this series is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields.
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Neurodegenerative diseases and oxidative stress.
TL;DR: Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and different strategies, including novel metal–protein attenuating compounds aimed at a variety of targets have shown promise in clinical studies.
Journal ArticleDOI
Structural considerations in the interaction of DNA and acridines.
L.S. Lerman,L.S. Lerman +1 more
TL;DR: The proposed structural change is compatible with the normal restrictions on bond lengths, angles, and non-bonded contacts, and maintenance of the hydrogen- bonded base pairs perpendicular to the axis of the molecule.
Journal ArticleDOI
The role of copper in neurodegenerative disease.
TL;DR: Current evidence suggests a direct pathogenic role for copper in the pathogenesis of neuronal injury in Alzheimer's disease and the prion-mediated encephalopathies, suggesting that further elucidation of the mechanisms of copper trafficking and metabolism within the nervous system will be of direct relevance to the pathophysiology and treatment of neurodegenerative disease.