Journal ArticleDOI
Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy.
Ralph H.B. Benedict,Deepa P. Ramasamy,Frederick Munschauer,Bianca Weinstock-Guttman,Robert Zivadinov +4 more
TLDR
For the first time, the predictive validity of MTL and DGM atrophy were simultaneously compared with MS using reliable and validated neuropsychological measures and found that both compartments play significant but different roles in the amnesia of MS.Abstract:
Background: MRI research in multiple sclerosis (MS) samples reveals pathology in both the cerebral cortex and deep grey matter (DGM). The classical subcortical dementia hypothesis has been ascribed to MS and is supported by studies highlighting the role of thalamic atrophy in neuropsychological outcomes. However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM. Objective: To determine the relative importance of MTL and DGM structures in predicting MS performance on memory tests presented in the auditory/verbal and visual/spatial spheres. Methods: Cross sectional analysis of 50 patients with MS undergoing structural brain MRI and neuropsychological testing. Using Freesurfer software, the volumes of the MTL (hippocampus, amygdala) and DGM (thalamus, caudate) structures were calculated and compared with control values. Neuropsychological testing contributed measures of new learning, delayed recall and recognition memory, in the auditory/verbal and visual/spatial memory modalities. Results: Significant correlations between lower regional volume and poorer test performance were observed across all memory tests. For measures of free recall or new learning, DGM volumes were most strongly predictive of outcomes. In contrast, measures of recognition memory were predicted only by MTL volumetric measures. Conclusion: For the first time, the predictive validity of MTL and DGM atrophy were simultaneously compared with MS using reliable and validated neuropsychological measures. This study found that both compartments play significant but different roles in the amnesia of MS.read more
Citations
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Journal ArticleDOI
Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)
Dawn Langdon,Maria Pia Amato,J B Boringa,Bruno Brochet,Frederick W. Foley,Sten Fredrikson,Päivi Hämäläinen,H.-P. Hartung,Lauren B. Krupp,Iris-Katharina Penner,Anthony T. Reder,Ralph H.B. Benedict +11 more
TL;DR: A brief cognitive assessment for multiple sclerosis that is optimized for small centers, with one or few staff members, who may not have neuropsychological training and constructed to maximize international use is recommended.
Journal ArticleDOI
Cortical Lesions and Atrophy Associated With Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis
Massimiliano Calabrese,Federica Agosta,Francesca Rinaldi,Irene Mattisi,Paola Grossi,Alice Favaretto,M Atzori,Valentina Bernardi,Luigi Barachino,Luciano Rinaldi,Paola Perini,Paolo Gallo,Massimo Filippi +12 more
TL;DR: The burden of CLs and tissue loss are among the major structural changes associated with cognitive impairment in relapsing-remitting MS.
Journal ArticleDOI
The Effects of FreeSurfer Version, Workstation Type, and Macintosh Operating System Version on Anatomical Volume and Cortical Thickness Measurements
Ed H.B.M. Gronenschild,Ed H.B.M. Gronenschild,Petra Habets,Petra Habets,Heidi I.L. Jacobs,Heidi I.L. Jacobs,Ron Mengelers,Ron Mengelers,Nico Rozendaal,Nico Rozendaal,Jim van Os,Jim van Os,Jim van Os,Machteld Marcelis,Machteld Marcelis +14 more
TL;DR: The main conclusion is that users are discouraged to update to a new major release of either FreeSurfer or operating system or to switch to a different type of workstation without repeating the analysis; results thus give a quantitative support to successive recommendations stated by FreeSurf developers over the years.
Journal ArticleDOI
Risk factors for and management of cognitive dysfunction in multiple sclerosis
TL;DR: It is found that the heterogeneity in neuropsychological presentation among patients with MS reflects the influence of many factors, including genetics, sex, intelligence, disease course, comorbid neuropsychiatric illness, and health behaviors.
Journal ArticleDOI
Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
Sónia Batista,Robert Zivadinov,Marietta Hoogs,Niels Bergsland,M. Heininen-Brown,Michael G. Dwyer,Bianca Weinstock-Guttman,Ralph H.B. Benedict +7 more
TL;DR: The significant role of thalamus atrophy in MS-related IPS slowing is confirmed and it is found that putamen atrophy is also a significant contributor to this disorder.
References
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