Journal ArticleDOI
Meroterpenoids and a naphthoquinone from Arnebia euchroma and their cytotoxic activity.
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TLDR
Four new meroterpenoids, arnebinols A-D (1-4), and one new prenylated naphthoquinone, 5,8-O-dimethyl-11-deoxyalkannin (5) were isolated from the roots of Arnebia euchroma by spectroscopic data analysis and X-ray-single crystal diffraction analysis.Abstract:
Four new meroterpenoids, arnebinols A–D (1–4), and one new prenylated naphthoquinone, 5,8-O-dimethyl-11-deoxyalkannin (5), together with seven known meroterpenoids (6–12) were isolated from the roots of Arnebia euchroma. The structures of the isolated compounds were elucidated unambiguously by spectroscopic data analysis, as well as X-ray-single crystal diffraction analysis. Arnebinol A (1) and B (2) are rare meroterpenoids possessing a 6/10/5 tricyclic ring system. Compounds 1–12 were evaluated for their cytotoxicities against MG-63 and SNU387 human cancer cell lines. Compound 5 exhibited the most potent activity with IC50 values of 2.69 µM and 6.08 µM, respectively.read more
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Antibacterial and cytotoxic activities of naphthoquinone pigments from Onosma visianii Clem
Milena Vukić,Nenad Vuković,Gorica T. Djelic,Suzana Popovic,Milan Zaric,Dejan Baskic,Gordana Krstić,Vele Tešević,Miroslava Kačániová +8 more
TL;DR: The results indicated that all tested naphthoquinone pigments are potential candidates for clinical uses as antibacterial and cytotoxic agents.
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Systematic identification of shikonins and shikonofurans in medicinal Zicao species using ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry combined with a data mining strategy
TL;DR: An integral approach using UHPLC-ESI-QTOF-MS and CID-MS/MS analyses together with a novel two steps data mining strategy was developed for systematic analysis of shikonins and shik onofurans in complex samples and 58 compounds including 32 novel ones were efficiently discovered and identified from the crude extract of Zicao.
Journal ArticleDOI
Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity.
TL;DR: Four new naphthoquinones, including a dimeric one, shikometabolin G (1), together with six known ones (6-10), were isolated from the methanol extract of Onosma paniculatum and their structures were established based on the analysis of NMR and MS spectroscopic data.
Journal ArticleDOI
Arnebia euchroma, a Plant Species of Cold Desert in the Himalayas, Harbors Beneficial Cultivable Endophytes in Roots and Leaves.
TL;DR: A. euchroma is an endangered medicinal plant that grows naturally in extreme cold and arid environments in the Himalayas as mentioned in this paper, and it can be used for improving stress tolerance in plants under nutrient-deficient and cold/arid conditions.
Journal ArticleDOI
Identification, in vitro evaluation and modeling studies of the constituents from the roots of Arnebia euchroma for antitumor activity and STAT3 inhibition.
TL;DR: Investigation of the roots of Arnebia euchroma led to the isolation of a new dimeric naphthoquinone, shikometabolin H, a new meroterpeniod, epoxyarnebinol and a new ring A-seco hopane triterpenoid, 2, 3-secodiplopterol dioic acid (7), together with 18 known compounds.