Metabonomics identifies serum metabolite markers of colorectal cancer.
Binbin Tan,Yunping Qiu,Xia Zou,Tianlu Chen,Guoxiang Xie,Yu Cheng,Tao-Tao Dong,Linjing Zhao,Bo Feng,Xiaofang Hu,Lisa X. Xu,Aihua Zhao,Menghui Zhang,Guoxiang Cai,Sanjun Cai,Zhanxiang Zhou,Minhua Zheng,Yan Zhang,Wei Jia +18 more
TLDR
A follow-up replication study aiming to identify a distinct serum metabolic signature of CRC with diagnostic potential demonstrated that a panel of serum metabolite markers is of great potential as a noninvasive diagnostic method for the detection of CRC.Abstract:
Recent studies suggest that biofluid-based metabonomics may identify metabolite markers promising for colorectal cancer (CRC) diagnosis We report here a follow-up replication study, after a previous CRC metabonomics study, aiming to identify a distinct serum metabolic signature of CRC with diagnostic potential Serum metabolites from newly diagnosed CRC patients (N = 101) and healthy subjects (N = 102) were profiled using gas chromatography time-of-flight mass spectrometry (GC–TOFMS) and ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC–QTOFMS) Differential metabolites were identified with statistical tests of orthogonal partial least-squares-discriminant analysis (VIP > 1) and the Mann–Whitney U test (p < 005) With a total of 249 annotated serum metabolites, we were able to differentiate CRC patients from the healthy controls using an orthogonal partial least-squares-discriminant analysis (OPLS-DA) in a learning sample set of 62 CRC patients and 62 matched healtread more
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Colorectal cancer detection using targeted serum metabolic profiling.
Jiangjiang Zhu,Danijel Djukovic,Lingli Deng,Lingli Deng,Haiwei Gu,Farhan Himmati,E. Gabriela Chiorean,E. Gabriela Chiorean,Daniel Raftery,Daniel Raftery +9 more
TL;DR: A targeted liquid chromatography-tandem mass spectrometry-based metabolic profiling approach for identifying biomarker candidates that could enable highly sensitive and specific CRC detection using human serum samples is presented.
Journal ArticleDOI
Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential.
TL;DR: Current knowledge on the healthy microbiome of the gut and how it is altered in colorectal cancer and other related disease conditions is surveyed and a special focus on host-microbiome interaction mechanisms that may be important to explain how dysbiosis can lead to chronic inflammation and drive processes that influence carcinogenesis and tumor progression in colon cancer.
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Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery.
Seema Patel,Shadab Ahmed +1 more
TL;DR: The authors scoured through the most recent, high-impact papers archived in Pubmed, ScienceDirect, Wiley and Springer databases to compile this review to pique the interest of researchers towards cancer metabolomics.
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Advances in Lipidomics for Cancer Biomarkers Discovery
F. Perrotti,Consuelo Rosa,Ilaria Cicalini,Paolo Sacchetta,Piero Del Boccio,Domenico Genovesi,Damiana Pieragostino +6 more
TL;DR: The novel lipidomic biomarkers are reviewed in an effort to underline their role in diagnosis, in prognostic characterization and in prediction of therapeutic outcomes, and a lipidomic investigation through mass spectrometry highlights new insights on molecular mechanisms underlying cancer disease.
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Mass Spectrometric Analysis of Exhaled Breath for the Identification of Volatile Organic Compound Biomarkers in Esophageal and Gastric Adenocarcinoma.
Sacheen Kumar,Juzheng Huang,Nima Abbassi-Ghadi,Hugh Mackenzie,Kirill Veselkov,Jonathan Hoare,Laurence Lovat,Patrik Španěl,David Smith,George B. Hanna +9 more
TL;DR: Distinct exhaled breath VOC profiles can distinguish patients with esophageal and gastric adenocarcinoma from noncancer controls, as well as identify potentially curable upper gastrointestinal malignancies.
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