In this article, the authors discuss the current advancements and latest breakthroughs in the fabrication of mesoporous silica nanoparticles, emphasizing the pros and cons, the confinement of various metal species in the nanospaces of MSNs, and various factors influencing the encapsulation of metal species.
Abstract:
Despite their advantageous morphological attributes and attractive physicochemical properties, mesoporous silica nanoparticles (MSNs) are merely supported as carriers or vectors for a reason. Incorporating various metal species in the confined nanospaces of MSNs (M-MSNs) significantly enriches their mesoporous architecture and diverse functionalities, bringing exciting potentials to this burgeoning field of research. These incorporated guest species offer enormous benefits to the MSN hosts concerning the reduction of their eventual size and the enhancement of their performance and stability, among other benefits. Substantially, the guest species act through contributing to reduced aggregation, augmented durability, ease of long-term storage, and reduced toxicity, attributes that are of particular interest in diverse fields of biomedicine. In this review, the first aim is to discuss the current advancements and latest breakthroughs in the fabrication of M-MSNs, emphasizing the pros and cons, the confinement of various metal species in the nanospaces of MSNs, and various factors influencing the encapsulation of metal species in MSNs. Further, an emphasis on potential applications of M-MSNs in various fields, including in adsorption, catalysis, photoluminescence, and biomedicine, among others, along with a set of examples is provided. Finally, the advances in M-MSNs with perspectives are summarized.
TL;DR: The scope of the advancement in terms of structural and physicochemical attributes and their effects on biomedical applications with a particular focus on recent studies is emphasized.
TL;DR: The fabrication of a versatile nanoformulation by conveniently wrapping the ultrasmall platinum (Pt) nanoparticles-dispersed chitosan (CS) over the zinc-doped mesoporous silica nanocarriers (Zn-MSNs) through a facile, yet efficient self-assembly approach potentially allow for deep tumor penetration and synergistic ablation of the tumor by conveniently combating the MDR efficaciously.
TL;DR: The intracellular pathways of nanoparticles are summarized, highlighting the principles and state of their destructive effects in the subcellular structures as well as the current limitations of conventional therapeutic approaches to address the contemporary challenges in their clinical applicability.
TL;DR: A comprehensive review on the synthesis of porous bioactive glass micro/nanospheres (PBGSs) is presented in this paper, where the influence of pore-forming templates on the morphology of PBGSs is highlighted.
TL;DR: Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.
TL;DR: Use of amphiphilic triblock copolymers to direct the organization of polymerizing silica species has resulted in the preparation of well-ordered hexagonal mesoporous silica structures (SBA-15) with uniform pore sizes up to approximately 300 angstroms.
TL;DR: Corma et al. as mentioned in this paper used the Dupont Award on new materials (1995), and the Spanish National Award “Leonardo Torres Quevedo” on Technology Research (1996) on technology research (1996), to recognize the performance of zeolites as catalysts for oil refining and petrochemistry.
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.
TL;DR: The unique structure of MCM-41 silicates has provided for extremely attractive properties such as uniform pore sizes greater than 20 A, surface areas exceeding 1000 m2 g−1, and long-range ordering of the pores.
Q1. What are the contributions in "Evidence of clinical competence by simulation, a hermeneutical observational study" ?
In this paper, the authors presented a study of second-year bachelor degree nursing students in one university of applied sciences in Finland which is engaged in simulation training.
Q2. What have the authors stated for future works in "Evidence of clinical competence by simulation, a hermeneutical observational study" ?
To succeed in this, students need to come to the simulations prepared, and they need to study by themselves.
Q3. What are the three basic plots of the hermeneutical interpretation of the way from suffering?
In the hermeneutical interpretation of the way from suffering to health, three basic plots were found: 1) doing as performing and knowing.
Q4. What is the alternative to clinical training?
Simulation can be used to evaluate clinical competence, and when there is a lack of good and varying clinical training places, simulation is a good alternative.
Q5. What were the main factors used in the study?
The researcher's pre-understanding (Lejonqvist et al. 2011), familiarity with simulation teaching, the students' curriculum and the simulation centre were used in interpreting the situations.
Q6. What were the main categories of competence in the simulated situations?
Maturing and development were least seen in single scenarios but showed in the students' asking questions, sharing knowledge, verifyingwith peers, consulting and suggesting actions.