Journal ArticleDOI
Metalated carboxylic acids. II. Monoalkylation of metalated toluic acids and dimethylbenzoic acids
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This article is published in Journal of the American Chemical Society.The article was published on 1970-03-01. It has received 87 citations till now.read more
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An Anion-Induced Regio- and Chemoselective Acylation and Its Application to the Synthesis of an Anticancer Agent
TL;DR: A novel anisole-based Grignard reagent was developed to effect the cyclization of sterically hindered substrates and has been successfully applied to the synthesis of Sch 66336, a candidate for oncologic treatment.
Journal ArticleDOI
Advances in the Chemistry of Ambident Enolate and Phenoxide Ions
O. A. Reutov,A. L. Kurts +1 more
TL;DR: In this article, the authors examined the reactivities of ambident enolate and phenoxide ions in alkylation reactions and showed that the mode of C- and O-alkylation of an ambident anion is determined by the structures of the alkyl group and the group eliminated from the alkaline agent, the nature of the solvent, and the type of counter ion.
Journal ArticleDOI
Applications of Enantioselective Carbolithiation of Ortho-Substituted β-Methylstyrenes
TL;DR: The enantioselective carbolithiation of ortho-substituted (E)-beta-methylstyrenes provides access to chiral lithiated intermediates with broad synthetic potential in the synthesis of chiral aromatics and heteroaromatics.
Reference EntryDOI
Lateral Lithiation Reactions Promoted by Heteroatomic Substituents
Robin D. Clark,Alam Jahangir +1 more
TL;DR: The relationship of lateral lithiation reactions to heteroatom-facilitated ortho lithiations is obvious and the two fields have developed, for the most part, in concert as mentioned in this paper.
Journal ArticleDOI
α-Carbalkoxylations of carboxylic acids. A general synthetic route to monoesters of malonic acids.
TL;DR: Aus den Carbonsauren (I) entstehen mit Lithium-diisopropylamid die Li-Derivate (II), die mit Chlorkohlensaureester (III) oder Dialkyl carbonaten (V) zu den Malonester=Carbonsaurer (IV) substituiert werden as mentioned in this paper.