Metastatic emphysema a mechanism for acquiring inguinal herniation
Donald J. Cannon,Raymond C. Read +1 more
TLDR
The results indicate that an imbalance between blood proteases and antiproteases, resulting from chronic smoking can damage connective tissue in the groin as well as the lung.Abstract:
Since our previous work had indicated that veterans with inguinal herniation demonstrated qualitative and quantitative changes in connective tissue, we tested the hypothesis that a possible mechanism for the defect was chronic exposure to circulating proteases generated in the lung by cigarette smoke We investigated 59 men (average age: 60 years) with eigher primary direct of indirect hernias Most of the patients smoked Circulating serum elastolytic activity was significantly greater in patients with direct hernias who smoked when compared with controls (p less than 0001) In addition, the serum alpha-1-antitrypsin inhibitory capacity was significantly lower in this category than controls (p less than 0001) Patients with indirect defects who smoked also had significantly higher elastolytic values but to a lesser degree (p less than 001) Serum antiprotease and protein concentrations were within the normal range in all categories Our results indicate that an imbalance between blood protease and antiproteases, resulting from chronic smoking can damage connective tissue in the groin as well as the lungread more
Citations
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European Hernia Society guidelines on the treatment of inguinal hernia in adult patients
M. P. Simons,Th. J. Aufenacker,M Bay-Nielsen,J. L. Bouillot,Giampiero Campanelli,Joachim Conze,D. H. de Lange,René H. Fortelny,T. Heikkinen,Andrew N. Kingsnorth,J. Kukleta,Salvador Morales-Conde,Pär Nordin,Volker Schumpelick,S. Smedberg,M. Smietanski,G. Weber,Marc Miserez +17 more
TL;DR: The EHS Guidelines for the Treatment of Inguinal Hernia in Adult Patients contain recommendations for the treatment of inguinal hernia from diagnosis till aftercare and provide recommendations for further research that can be performed to raise the level of evidence concerning certain aspects of ingUinalHernia treatment.
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Life Table analysis of stomal complications following colostomy
TL;DR: The evidence in this study that spans a 22-year period questions much surgical technical dogma and raises the possibility that parastomal hernias may represent a failure in the transversalis fascia that might technically be avoidable.
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Systemic effects of smoking
TL;DR: Evidence indicates that nicotine releases endorphins, which account for the addiction, and surgeons need to do more to combat this menace.
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Smoking is a risk factor for incisional hernia
TL;DR: Smoking is a significant risk factor for incisional hernia in line with relaparotomy, postoperative wound complications, older age, and male sex.
References
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Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
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The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency
Carl-Bertil Laurell,S. Eriksson +1 more
TL;DR: In this paper, the Electrophoretic α, 1-Globulin Pattern of Serum in α; 1-Antitrypsin Deficiency; and 1-Girdhar et al.
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Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans.
TL;DR: Determination of the antielastase activity of alpha 1-antitrypsin revealed a nearly twofold reduction in the functional activity of this elastase inhibitor in the lungs of cigarette smokers, suggesting that cigarette smokers may lose some of the normal antiElastase protective screen of the lower respiratory tract, making them more vulnerable to destructive lung disease.