Journal ArticleDOI
Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.
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TLDR
Investigation in diabetic rats found that metformin is able to attenuate diabetes-induced hyperalgesia and allodynia, which might be associated its anti-oxidative effect through AMPK pathway, and might be used as an effective drug for abnormal sensation in painful diabetic neuropathy.About:
This article is published in European Journal of Pharmacology.The article was published on 2015-10-05. It has received 96 citations till now. The article focuses on the topics: Allodynia & Hyperalgesia.read more
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Metformin – a Future Therapy for Neurodegenerative Diseases
Magdalena Markowicz-Piasecka,Joanna Sikora,Aleksandra Szydłowska,Agata Skupień,Elżbieta Mikiciuk-Olasik,Kristiina M. Huttunen +5 more
TL;DR: Results of several clinical studies confirm that long term use of metformin in diabetic patients contributes to better cognitive function, compared to participants using other anti-diabetic drugs.
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Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets.
Saikat Dewanjee,Sonjit Das,Anup K. Das,Niloy Bhattacharjee,Anjum Dihingia,Tarun K. Dua,Jatin Kalita,Prasenjit Manna,Prasenjit Manna +8 more
TL;DR: The main aim of this review is to highlight the putative role of various mechanisms and pathways involved in the development of diabetic neuropathy and to impart an in‐depth insight on new therapeutic approaches aimed at delaying or reversing various modalities of diabetic Neuropathy.
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Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway.
TL;DR: It is found that meetformin effectively alleviated the disorders of glycolipid metabolism, renal function injury in diabetic rats, and relieved oxidative stress, enhanced autophagy and slowed down abnormal cell proliferation in high glucose cultured RMCs through AMPK/SIRT1-FoxO1 pathway, indicating the protective role of metformin against the pathological process of DKD.
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Chemotherapy-induced peripheral neuropathy: where are we now?
TL;DR: No preventive therapies have shown significant clinical efficacy, although there are promising novel agents such as histone deacetylase 6 (HDAC6) inhibitors, currently in early phase clinical trials for cancer treatment, and drug repurposing, eg, metformin, may offer an alternative therapeutic avenue.
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AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration.
Christina Alves Peixoto,Christina Alves Peixoto,Wilma Helena de Oliveira,Shyrlene Meiry da Racho Araújo,Ana Karolina Santana Nunes +4 more
TL;DR: A review of the recent literature on the pharmacological modulation of the AMPK system as a potential molecular target in the management of neurodegenerative diseases is offered.
References
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Journal ArticleDOI
Quantitative assessment of tactile allodynia in the rat paw.
TL;DR: Threshold measurement using the up-down paradigm, in combination with the neuropathy pain model, represents a powerful tool for analyzing the effects of manipulations of the neuropathic pain state.
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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal Article
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
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Role of Oxidative Stress in Development of Complications in Diabetes
TL;DR: Structural characterization of the cross-links and other products accumulating in collagen in diabetes is needed to gain a better understanding of the relationship between oxidative stress and the development of complications in diabetes.
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Metformin: an update.
TL;DR: Treatment with an insulin-sensitizing agent, such as metformin, in patients with type 2 diabetes mellitus may correct several of the primary pathophysiological abnormalities of the metabolic syndrome.