Patent
Methods and compositions for risk prediction, diagnosis, prognosis, and treatment of pulmonary disorders
David A. Schwartz,Max A. Seibold +1 more
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TLDR
In this article, a genetic variant of the MUC5B gene was associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.Abstract:
The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.read more
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References
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Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
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Recombinant immunoglobin preparations
TL;DR: In this paper, a mixture of altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture, which contain variable regions which are immunologically capable of binding predetermined antigens.
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Using Antibodies: A Laboratory Manual
Ed Harlow,David A. Lane +1 more
TL;DR: Epitope Mapping Determining the Structural Requirements Of An Epitope Choosing An EpITope-mapping Method Mapping By Competition Assay Mapping by Expression of Gene Fragments Mapping Using Synthetic Peptides Synthesis Or Purchase Of The Peptide Set Alternate Approaches To Epitopes.
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Genetic Inhibition by Double-Stranded RNA
Andrew Fire,Stephen A. Kostas,Mary K. Montgomery,Lisa Timmons,SiQun Xu,Hiroaki Tabara,Samuel E. Driver,Craig C. Mello +7 more
TL;DR: In this article, a double-stranded RNA has been used to inhibit gene expression of a target gene in a living cell in order to identify the source and target genes in the cell.
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Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
TL;DR: In this paper, a polypeptide array can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoregressive group to the activated regions, and repeating the steps of activation and attachment until the desired length and sequences are synthesized.
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