Journal ArticleDOI
Methotrexate for the Treatment of Crohn's Disease
Brian G. Feagan,J. Rochon,Richard N. Fedorak,E J Irvine,Gary Wild,Lloyd R. Sutherland,A H Steinhart,Gordon R. Greenberg,R Gillies,Marybeth Hopkins +9 more
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In a group of patients with chronically active Crohn's disease, methotrexate was more effective than placebo in improving symptoms and reducing requirements for prednisone.Abstract:
Background Although corticosteroids are highly effective in improving symptoms of Crohn's disease, they may have substantial toxicity. In some patients, attempts to discontinue corticosteroids are ...read more
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Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
Stephen B. Hanauer,Brian G. Feagan,Gary R. Lichtenstein,Lloyd Mayer,Stefan Schreiber,Jean-Frederic Colombel,Daniel Rachmilewitz,Douglas C. Wolf,Allan Olson,Weihang Bao,Paul Rutgeerts +10 more
TL;DR: Patients with Crohn's disease who respond to an initial dose of infliximab are more likely to be in remission at weeks 30 and 54, to discontinue corticosteroids, and to maintain their response for a longer period of time, if inflIXimab treatment is maintained every 8 weeks.
Journal ArticleDOI
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.
Stephan R. Targan,Stephen B. Hanauer,S. J. H. Van Deventer,Lloyd Mayer,Daniel H. Present,T. Braakman,K. L. Dewoody,T. F. Schaible,Paul Rutgeerts +8 more
TL;DR: A 12-week multicenter, double-blind, placebo-controlled trial of cA2 in 108 patients with moderate-to-severe Crohn's disease that was resistant to treatment, finding clinical response, the primary end point, was a reduction of 70 or more points in the score on theCrohn's Disease Activity Index at four weeks.
Journal ArticleDOI
Inflammatory bowel disease: clinical aspects and established and evolving therapies.
TL;DR: The current diagnostic approach, their pathology, natural course, and common complications, the assessment of disease activity, extraintestinal manifestations, and medical and surgical management are discussed, and diagnostic and therapeutic algorithms are provided.
Journal ArticleDOI
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management
Axel Dignass,G. Van Assche,James O. Lindsay,Marc Lémann,Johan D. Söderholm,Jean-Frederic Colombel,Silvio Danese,André D'Hoore,Miquel A. Gassull,Fernando Gomollón,Daan W. Hommes,Pierre Michetti,Colm O'Morain,Tom Øresland,Alastair Windsor,Eduard F. Stange,Simon Travis +16 more
TL;DR: This paper is the second in a series of three publications relating to the European evidence-based consensus on the diagnosis and management of Crohn's disease and concerns the management of active disease, maintenance of medically induced remission and surgery.
Journal ArticleDOI
Guidelines for the management of inflammatory bowel disease in adults
Craig Mowat,Andrew Cole,Al Windsor,Tariq Ahmad,Ian D. Arnott,R Driscoll,Sally G. Mitton,Timothy R. Orchard,Matthew D. Rutter,Lisa Younge,Charlie W. Lees,Gwo-Tzer Ho,Jack Satsangi,Stuart Bloom +13 more
TL;DR: The present document is intended primarily for the use of clinicians in the United Kingdom, and serves to replace the previous BSG guidelines in IBD, while complementing recent consensus statements published by the European Crohn's and Colitis Organisation (ECCO).
References
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Generalized linear models. 2nd ed.
Peter McCullagh,John A. Nelder +1 more
TL;DR: A class of statistical models that generalizes classical linear models-extending them to include many other models useful in statistical analysis, of particular interest for statisticians in medicine, biology, agriculture, social science, and engineering.
Journal ArticleDOI
Generalized Linear Models
TL;DR: Generalized linear models, 2nd edn By P McCullagh and J A Nelder as mentioned in this paper, 2nd edition, New York: Manning and Hall, 1989 xx + 512 pp £30
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Development of a Crohn's Disease Activity Index: National Cooperative Crohn's Disease Study
TL;DR: In this paper, a multiple regression computer program was utilized to derive an equation for prediction of the physician's over-all ratings from a subset of the predictor variables fulfilling a combination of constraints.
Journal ArticleDOI
Unbalanced repeated-measures models with structured covariance matrices
TL;DR: This work addresses the question of how to analyze unbalanced or incomplete repeated-measures data through maximum likelihood analysis using a general linear model for expected responses and arbitrary structural models for the within-subject covariances.