Journal ArticleDOI
Microbubble ultrasound contrast agents: a review.
Eleanor Stride,Nader Saffari +1 more
- Vol. 217, Iss: 6, pp 429-447
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TLDR
In this review the existing theoretical and experimental evidence is examined in order to clarify the extent to which contrast agents are currently understood and to identify areas for future research.Abstract:
The superior scattering properties of gas bubbles compared with blood cells have made microbubble ultrasound contrast agents important tools in ultrasound diagnosis. Over the past 2 years they have become the focus of a wide and rapidly expanding field of research, with their benefits being repeatedly demonstrated, both in ultrasound image enhancement, and more recently in drug and gene delivery applications. However, despite considerable investigation, their behaviour is by no means fully understood and, while no definite evidence of harmful effects has been obtained, there remain some concerns as to their safety. In this review the existing theoretical and experimental evidence is examined in order to clarify the extent to which contrast agents are currently understood and to identify areas for future research. In particular the disparity between the conditions considered in theoretical models and those encountered both in vitro, and more importantly in vivo is discussed, together with the controversy regarding the risk of harmful bio-effects.read more
Citations
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Journal ArticleDOI
Nanoplatforms for targeted molecular imaging in living subjects.
Weibo Cai,Xiaoyuan Chen +1 more
TL;DR: The current state-of-the-art of nanoplatforms for targeted molecular imaging in living subjects is summarized.
Journal ArticleDOI
Ultrasound contrast agents: An overview
TL;DR: Clinical roles of contrast enhanced ultrasound scanning are expanding rapidly and considerations suggest that contrast-enhanced ultrasound might have a role in abdominal trauma: injury to the liver, spleen and kidneys can be assessed rapidly and repeatedly if necessary and its role here alongside dynamic CT remains to be evaluated.
Journal ArticleDOI
Sonoporation from Jetting Cavitation Bubbles
Claus-Dieter Ohl,Manish Arora,Roy Ikink,Nico de Jong,Michel Versluis,Michael Delius,Detlef Lohse +6 more
TL;DR: It is found that the nonspherical collapse of bubbles near to the boundary is responsible for cell detachment, and high-speed photography reveals that a wall bounded flow leads to the detachment of cells.
Journal ArticleDOI
Engineered nanoparticles for biomolecular imaging
TL;DR: The physics of various imaging methods, including MRI, optical techniques, X-rays and CT will be described, and the effect of NPs on the improvement of the mentioned non-invasive imaging methods will be discussed together with their advantages and disadvantages.
Journal ArticleDOI
Novel microbubble preparation technologies
Eleanor Stride,Mohan Edirisinghe +1 more
TL;DR: A review of the range of techniques available for microbubble preparation and how these have evolved to keep pace with advances in clinical practice is presented in this article, where the authors discuss the potential for use in therapeutic applications including targeted drug delivery, gene therapy, thrombolysis and focused ultrasound surgery.
References
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Book
The Acoustic Bubble
TL;DR: In this article, the authors present a bibliographie (a la fin de chaque chapitre), and index reference record created on 2004-09-07, modified on 2016-08-08
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On the Capillary Phenomena of Jets
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Quantification of Myocardial Blood Flow With Ultrasound-Induced Destruction of Microbubbles Administered as a Constant Venous Infusion
TL;DR: MBF can be quantified with myocardial contrast echocardiography during a venous infusion of microbubbles and has potential for measuring tissue perfusion in any organ accessible to ultrasound.
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The Dynamics of Cavitation Bubbles
TL;DR: In this paper, three regimes of liquid flow over a body are defined, namely: (a) noncavitating flow, (b) cavitating flow with a relatively small number of cavitation bubbles in the field of flow, and (c) caviting flow with one large cavity about the body.
Journal ArticleDOI
Collapse of an initially spherical vapour cavity in the neighbourhood of a solid boundary
TL;DR: In this paper, a numerical method was proposed to solve the problem of balloon bubble collapse near a plane solid wall, using finite time steps and an iterative technique for applying the boundary conditions at infinity directly to the liquid at a finite distance from the free surface.