Journal ArticleDOI
Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery.
TLDR
This review offers a critical analysis of the state of the art of medical microbubbles and their application in therapeutic delivery and monitoring and potential clinical applications.Abstract:
This review offers a critical analysis of the state of the art of medical microbubbles and their application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse, these small gas bubbles oscillate with a wall velocity on the order of tens to hundreds of meters per second and can be deflected to a vessel wall or fragmented into particles on the order of nanometers. While single-session molecular imaging of multiple targets is difficult with affinity-based strategies employed in some other imaging modalities, microbubble fragmentation facilitates such studies. Similarly, a focused ultrasound beam can be used to disrupt delivery vehicles and blood vessel walls, offering the opportunity to locally deliver a drug or gene. Clinical translation of these vehicles will require that current challenges be overcome, where these challenges include rapid clearance and low payload. The technology, early successes with drug and gene delivery, and potential clinical applications are reviewed.read more
Citations
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Journal ArticleDOI
Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms ☆
TL;DR: The mechanisms contributing to sonoporation are categorized according to three ultrasound settings: i) low intensity ultrasound leading to stable cavitation of microbubbles, ii) high intensity ultrasound leads to inertial cavitation with microbubble collapse, and iii) ultrasound application in the absence ofmicrobubbles.
Journal ArticleDOI
Advances in Biomaterials for Drug Delivery.
TL;DR: Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine, including major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing.
Journal ArticleDOI
Overview of Therapeutic Ultrasound Applications and Safety Considerations
Douglas L. Miller,Nadine Barrie Smith,Michael R. Bailey,Gregory J. Czarnota,Kullervo Hynynen,Inder Raj S. Makin +5 more
TL;DR: The Bioeffects Committee of the American Institute of Ultrasound in Medicine outlines the wide range of therapeutic ultrasound methods, which are in clinical use or under study, and provides general guidance for ensuring therapeutic ultrasound safety.
Journal ArticleDOI
Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles.
TL;DR: No therapeutic effect from the nanodroplet/ultrasound combination was observed without the drug, indicating that therapeutic effect was caused by the ultrasound-enhanced chemotherapeutic action of the tumor-targeted drug, rather than the mechanical or thermal action of ultrasound itself.
Journal ArticleDOI
Microbubble Compositions, Properties and Biomedical Applications
Shashank R. Sirsi,Mark A. Borden +1 more
TL;DR: In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery.
References
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TL;DR: In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this inducible rabbit endothelial adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions, suggesting a potential endothelia-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis.
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Quantification of Myocardial Blood Flow With Ultrasound-Induced Destruction of Microbubbles Administered as a Constant Venous Infusion
TL;DR: MBF can be quantified with myocardial contrast echocardiography during a venous infusion of microbubbles and has potential for measuring tissue perfusion in any organ accessible to ultrasound.
Journal ArticleDOI
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness
Hiroya Hashizume,Peter Baluk,Shunichi Morikawa,John W. McLean,Gavin Thurston,Sylvie Roberge,Rakesh K. Jain,Donald M. McDonald +7 more
TL;DR: It is concluded that some tumor vessels have a defective cellular lining composed of disorganized, loosely connected, branched, overlapping or sprouting endothelial cells that contribute to tumor vessel leakiness and may permit access of macromolecular therapeutic agents to tumor cells.
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On the stability of gas bubbles in liquid-gas solutions
Paul S. Epstein,M. S. Plesset +1 more
TL;DR: In this article, approximate solutions for the rate of solution by diffusion of a gas bubble in an undersaturated liquid-gas solution are presented, with the neglect of the translational motion of the bubble.
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Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke.
Andrei V. Alexandrov,Andrei V. Alexandrov,Carlos A. Molina,James C. Grotta,Zsolt Garami,Shiela R. Ford,José Alvarez-Sabín,Joan Montaner,Maher Saqqur,Andrew M. Demchuk,Lemuel A. Moyé,Michael D. Hill,Anne W. Wojner +12 more
TL;DR: In patients with acute ischemic stroke, continuous transcranial Doppler augments t-PA-induced arterial recanalization, with a nonsignificant trend toward an increased rate of recovery from stroke, as compared with placebo.