Journal ArticleDOI
Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia.
Seiji Futagami,Tomotaka Shindo,Tetsuro Kawagoe,Akane Horie,Mayumi Shimpuku,Katya Gudis,Katsuhiko Iwakiri,Takashi Itoh,Choitsu Sakamoto +8 more
TLDR
Migration of inflammatory cells, in particular, duodenal CCR2-positive macrophages, may have an important function in the pathophysiology of postinfectious FD patients.About:
This article is published in The American Journal of Gastroenterology.The article was published on 2010-05-11. It has received 120 citations till now. The article focuses on the topics: Duodenum.read more
Citations
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Journal ArticleDOI
Global Epidemiology of Campylobacter Infection
TL;DR: Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come.
Journal ArticleDOI
Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia
Hanne Vanheel,María Vicario,Tim Vanuytsel,Lukas Van Oudenhove,Cristina Martínez,Åsa V. Keita,Nicolas A. Pardon,Javier Santos,Johan D. Söderholm,Jan Tack,Ricard Farré +10 more
TL;DR: It is suggested that impaired intestinal barrier function is a pathophysiological mechanism in FD and restoration of intestinal barrier integrity may be a potential therapeutic target for treating patients with FD.
Journal ArticleDOI
The mucosal immune system: master regulator of bidirectional gut-brain communications.
TL;DR: The role of the immune system is considered as the gatekeeper and master regulator of brain–gut and gut–brain communications and how these key immune cells respond to environmental variables, including the microbiota, to alter gut homeostasis is considered.
Journal ArticleDOI
Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria.
Jan Tack,Nicholas J. Talley +1 more
TL;DR: Preliminary pathophysiological studies suggest that PDS might be characterized by a higher prevalence of impaired gastric accommodation than EPS and raised duodenal eosinophil counts, and whether different treatment approaches are needed for EPS and PDS is currently unclear.
Journal ArticleDOI
Evidence-based clinical practice guidelines for functional dyspepsia
Hiroto Miwa,Motoyasu Kusano,Tomiyasu Arisawa,Tadayuki Oshima,Mototsugu Kato,Takashi Joh,Hidekazu Suzuki,Kazunari Tominaga,Koji Nakada,Akihito Nagahara,Seiji Futagami,Noriaki Manabe,Akio Inui,Ken Haruma,Kazuhide Higuchi,Koji Yakabi,Michio Hongo,Naomi Uemura,Yoshikazu Kinoshita,Kentaro Sugano,Tooru Shimosegawa +20 more
TL;DR: The proposed pharmacological treatment is divided into two steps: initial treatment including an acid inhibitory drug (H2RA or PPI) or prokinetics, (strong recommendation); second-line treatment including anxiolytics, antidepressants, and Japanese traditional medicine (weak recommendation).
References
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Journal ArticleDOI
Classification and grading of gastritis.The updated Sydney system
TL;DR: The Sydney System for the classification of gastritis emphasized the importance of combining topographical, morphological, and etiological information into a schema that would help to generate reproducible and clinically useful diagnoses as discussed by the authors.
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The functional gastrointestinal disorders and the Rome III process.
TL;DR: Two important processes have occurred to legitimize these conditions, and to increase attention toward the research and clinical care of patients with functional gastrointestinal disorders (FGID), a shift in conceptualizing these disorders from a disease-based, reductionistic model, to a more integrated, biopsychosocial model of illness.
Journal ArticleDOI
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Robin C. Spiller,David Jenkins,John P. Thornley,John M. Hebden,Trina Wright,M Skinner,Keith R. Neal +6 more
TL;DR: Increased EC, T lymphocytes, and gut permeability are acute changes following Campylobacter enteritis which can persist for more than a year and may contribute to PD-IBS.
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Role of impaired gastric accommodation to a meal in functional dyspepsia
TL;DR: Impaired relaxation of the proximal stomach to a meal is present in a high proportion of patients with functional dyspepsia and is associated with symptoms of early satiety, and restoring gastric accommodation with a fundus-relaxing drug improves early satieties.