Journal ArticleDOI
Mite faeces are a major source of house dust allergens
TLDR
Measurements from a radioimmunoassay show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particles.Abstract:
The association between house dust allergy and asthma has long been recognized, and it has been demonstrated that a major allergen in house dust is related to the presence of mites of the genus Dermatophagoides Using extracts of mite culture for skin testing, as many as 10% of the population and up to 90% of allergic asthmatics give positive immediate reactions Although mites may occasionally become airborne during bed-making, it has also been demonstrated that they 'secrete or excrete' some allergen Recently, we have shown that up to three-quarters of the serum IgE antibodies to mites are directed against a major allergen-antigen P1 (molecular weight 24,000) Using a radioimmunoassay it is possible to measure the concentration of this glycoprotein in both dust samples and mite cultures These measurements, which are reported here, show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particlesread more
Citations
More filters
Journal ArticleDOI
Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood: a prospective study.
TL;DR: In addition to genetic factors, exposure in early childhood to house-dust mite allergens is an important determinant of the subsequent development of asthma.
Journal ArticleDOI
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
Hong Wan,Helen L Winton,Christian Soeller,Euan R. Tovey,Dieter C. Gruenert,Philip J. Thompson,Geoffrey A. Stewart,Graham W. Taylor,David R. Garrod,Mark B. Cannell,Clive Robinson +10 more
TL;DR: The results suggest that opening of TJs by environmental proteinases may be the initial step in the development of asthma to a variety of allergens.
Journal ArticleDOI
Dust mite allergens and asthma—A worldwide problem
Thomas A.E. Platts-Mills,Alain L. de Weck,R. C. Aalberse,Jean Claude Bessot,B. Bjorksten,Edelbert Bischoff,Jean Bousquet,J. E.M.H. Van Bronswijk,G. P. ChannaBasavanna,Martin C. Chapman,Matthew J. Colloff,Robert A. Goldstein,B. Guérin,Barbara Hart,Chein Soo Hong,Koji Ito,W. Jorde,Jens Korsgaard,J. Le Mao,Terumasa Miyamoto,P. Lind,Henning Løwenstein,E. B. Mitchell,Andrew B. Murray,D. Nolte,Philip S. Norman,Gabrielle Pauli,H. R. Ranganath,Charles E. Reed,Jan Reiser,Geoffrey A. Stewart,Keven J. Turner,Daniel Vervloet,Tinghuan Wen +33 more
TL;DR: Cette etude generale aborde successivement l'epidemiologie, l'entomologies, la methodologie pour la collecte and le traitement des echantillons de poussieres, the lutte contre les acariens.
Journal ArticleDOI
Reduction of bronchial hyperreactivity during prolonged allergen avoidance
Thomas A.E. Platts-Mills,E.Bruce Mitchell,Pauline Nock,EuanR. Tovey,Helen Moszoro,SusanR. Wilkins +5 more
TL;DR: Avoidance of important allergens seems not only to result in clinical remissions but in many cases also reduce bronchial hyperreactivity.
Journal ArticleDOI
EAACI Molecular Allergology User's Guide.
Paolo Maria Matricardi,Jörg Kleine-Tebbe,Hans Jürgen Hoffmann,Rudolf Valenta,Christiane Hilger,Stephanie Hofmaier,Rob C. Aalberse,Ioana Agache,Riccardo Asero,Barbara Ballmer-Weber,Domingo Barber,Kirsten Beyer,Tilo Biedermann,M. B. Bilò,Simon Blank,Barbara Bohle,Philipp P. Bosshard,Heimo Breiteneder,Helen A. Brough,Luis Caraballo,J-C Caubet,Reto Crameri,Janet M. Davies,Nikolaos Douladiris,M. Ebisawa,Philippe Eigenmann,Montserrat Fernandez-Rivas,Fatima Ferreira,Gabriele Gadermaier,Martin Glatz,Robert G. Hamilton,Thomas Hawranek,P W Hellings,Karin Hoffmann-Sommergruber,Thilo Jakob,Uta Jappe,Marek Jutel,Sandip D. Kamath,Edward F. Knol,Peter Korošec,Annette Kuehn,Gideon Lack,Gideon Lack,Andreas L. Lopata,Mika J. Mäkelä,Martine Morisset,Verena Niederberger,Anna Nowak-Wegrzyn,Nikolaos G. Papadopoulos,Elide A. Pastorello,Gabrielle Pauli,Thomas A.E. Platts-Mills,Daniela Posa,Lars K. Poulsen,Monika Raulf,Joaquín Sastre,Enrico Scala,Johannes Schmid,Peter Schmid-Grendelmeier,M. van Hage,R. van Ree,Stefan Vieths,Richard W. Weber,Magnus Wickman,Antonella Muraro,Markus Ollert +65 more
TL;DR: The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) as mentioned in this paper provides comprehensive information on important allergens and describes the diagnostic options using component-resolved diagnosis (CRD).
References
More filters
Journal Article
Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1.
Book ChapterDOI
Allergens and the Genetics of Allergy
TL;DR: It has been shown that, other than a tendency for allergens to be at the lower end of the molecular weight spectrum of antigens, there is no general chemical feature that characterizes allergens as a subpopulation of ants.
Journal ArticleDOI
Clinical significance of skin reactions to mite extracts in children with asthma.
TL;DR: Allergy to house-dust mites, particularly D. pteronyssinus, is of considerable importance in childhood asthma, and further study of the ecology and control of the mites in dust is desirable.
Journal ArticleDOI
The respiratory retention of bacterial aerosols: experiments with radioactive spores.
G. J. Harper,J. D. Morton +1 more
TL;DR: The distribution of inhaled bacterial aerosols has been studied in guinea-pigs, monkeys and mice, using Bacillus subtilis spores labelled with radiophosphorus, and the subsequent fate of the retained particles accords with what is known about ciliary removal.
Journal ArticleDOI
Mites in bedroom air.
A. M. Cunnington,P. H. Gregory +1 more
TL;DR: Among the many constituents of house dust causing allergic reactions of the respiratory tract (rhinitis and asthma) in people sensitive to house dust, a hitherto little known Pyroglyphid mite, Dermatophagoides pteronyssinus, contains allergens that are much more potent than those of other constituents.