Journal ArticleDOI
MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways.
Boris J. Cheskis,James G. Greger,Neil Cooch,Christopher McNally,Sean McLarney,Ho-Sun Lam,Su Jane Rutledge,Belew Mekonnen,Diane Hauze,Sunil Nagpal,Leonard P. Freedman +10 more
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TLDR
It is suggested that MNAR acts as an important scaffold that integrates ERa action in regulation of important signaling pathways, and evaluation of the molecular crosstalk between MNAR and ERa may lead to development of functionally selective ER modulators that can separate between beneficial, prodifferentiative effects in bone, the cardiovascular system and the CNS and the "detrimental", proliferative effects on reproductive tissues and organs.About:
This article is published in Steroids.The article was published on 2008-10-01. It has received 94 citations till now. The article focuses on the topics: Scaffold protein & Signal transduction.read more
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Book ChapterDOI
Estrogen receptor signaling mechanisms.
TL;DR: This chapter addresses the molecular events governing regulation of gene expression via the nuclear estrogen receptors (ERα, and ERβ) and the membrane estrogen receptor (GPER1) and describes mechanisms of cross-talk between signaling cascades activated by both nuclear and membrane estrogen receptors.
Journal ArticleDOI
Estrogen: a master regulator of bioenergetic systems in the brain and body.
TL;DR: By generating biomarker profiles that encompass peripheral metabolic changes occurring with menopause, individual risk profiles for decreased brain bioenergetics and cognitive decline can be created.
Journal ArticleDOI
Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms.
TL;DR: Past and current work in the laboratory on neuroendocrinology is summarized, including the study of estrogen receptors and estrogen actions on processes related to cognition, mood, autonomic regulation, pain, and neuroprotection.
Journal ArticleDOI
What are nuclear receptor ligands
TL;DR: The purpose of this review is to provide a broad perspective on NR ligands and address the issue of exactly what constitutes a NR ligand from historical, biological and evolutionary perspectives.
Journal ArticleDOI
Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways.
TL;DR: C Crosstalk between growth factors and steroids in both the cytoplasm and nucleus may have a profound impact on complex biological processes such as cell growth, and may play a significant role in the treatment of steroid-dependent breast cancers.
References
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Journal ArticleDOI
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
TL;DR: Experiments with PC12 cells suggest that the duration of ERK activation is critical for cell signaling decisions, and the extracellular signal-regulated kinase (ERK-regulated) MAPK pathway may be sufficient for these cellular responses.
Journal ArticleDOI
A signature motif in transcriptional co-activators mediates binding to nuclear receptors.
TL;DR: It is proposed that the LXXLL motif is a signature sequence that facilitates the interaction of different proteins with nuclear receptors, and is thus a defining feature of a new family of nuclear proteins.
Journal ArticleDOI
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Tommaso Simoncini,Ali Hafezi-Moghadam,Derek P. Brazil,Klaus Ley,William W. Chin,James K. Liao +5 more
TL;DR: It is shown that the ER isoform, ERα, binds in a ligand-dependent manner to the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI(3)K).
Journal ArticleDOI
Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.
Stavroula Kousteni,Teresita Bellido,Lilian I. Plotkin,Charles A. O'Brien,Donald L. Bodenner,Li Han,K. Han,G. B. DiGregorio,John A. Katzenellenbogen,Benita S. Katzenellenbogen,Paula K. Roberson,Robert S. Weinstein,Robert L. Jilka,Stavros C. Manolagas +13 more
TL;DR: A novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic fibroblasts, and HeLa cells involving activation of a Src/Shc/ERK signaling pathway and attenuating apoptosis is demonstrated, providing proof of principle for the development of function-specific-as opposed to tissue-selective-and gender-neutral pharmacotherapeutics.
Related Papers (5)
Mechanisms of Estrogen Receptor Signaling: Convergence of Genomic and Nongenomic Actions on Target Genes
Linda Björnström,Maria Sjöberg +1 more