Mode-Dependent Antiviral Activity of Medicinal Plant Extracts against the Mosquito-Borne Chikungunya Virus.
Sze Mun Chan,Kong Soo Khoo,Shamala Devi Sekaran,Nam Weng Sit +3 more
- Vol. 10, Iss: 8, pp 1658
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TLDR
In this article, 132 extracts obtained by sequential solvent extraction from 21 medicinal plants for cytopathic effect inhibitory activity using virus-infected Vero cells in two different sample introduction modes.Abstract:
The lack of specific treatment for chikungunya fever makes the need for anti-chikungunya virus agents more crucial. This study was conducted to evaluate 132 extracts obtained by sequential solvent extraction from 21 medicinal plants for cytopathic effect inhibitory activity using virus-infected Vero cells in two different sample introduction modes. Among the extracts, 42 extracts (31.8%) from 12 plants in the concurrent mode and three extracts (2.3%) from a plant in the non-concurrent mode displayed strong cytopathic effect inhibitory activity (cell viability ≥70%). Viral load quantification analysis unveiled that the extracts of Clinacanthus nutans (chloroform, ethyl acetate, and ethanol), Hydrocotyle sibthorpioides (ethanol), and Ocimum americanum (ethanol and methanol) hindered the release of viral progeny from the infected cells while the extracts of Ficus deltoidea (ethanol), Gynura bicolor (water), H. sibthorpioides (water), and O. americanum (chloroform and ethyl acetate) blocked the entry of virus into the cells. The extracts of Diodella sarmentosa (ethyl acetate), Diplazium esculentum (chloroform, ethyl acetate, and ethanol), and G. bicolor (ethanol) possessed virucidal effect and caused 5.41-log to 6.63-log reductions of viral load compared to the virus control. The results indicate that these medicinal plants are potential sources of anti-chikungunya virus agents that have varied modes of action.read more
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Antiviral and Immunomodulatory Activities of Clinacanthus nutans (Burm. f.) Lindau
TL;DR: In this paper , the authors conducted a panoramic survey of the literature regarding the immunoregulatory, anti-inflammatory, and antiviral activities of C. nutans and found that C. Nutans extracts have virucidal activities against herpes simplex virus types 1 and 2, varicella-zoster virus, cyprinid herpesvirus 3, porcine reproductive and respiratory syndrome virus, mosquito-borne chikungunya virus, and potentially SARS-CoV-2; such activities likely result from C.nutans interfering with the entry, penetration, infection, and replication of viruses.
Journal ArticleDOI
Ethyl palmitate, an anti-chikungunya virus principle from Sauropus androgynus, a medicinal plant used to alleviate fever in ethnomedicine.
A. Sagna,Reshma Vijayakumari Raveendran Nair,Neha V. Hulyalkar,S. Rajasekharan,Vinodkumar T G. Nair,Krishnan Sivakumar,S. R. Suja,Sabulal Baby,E. Sreekumar +8 more
TL;DR: Sauropus androgynus hydroalcoholic extract showed promising anti-CHIKV activity and its active component, obtained by activity guided isolation, was identified as ethyl palmitate (EP), a fatty acid ester as discussed by the authors .
Journal ArticleDOI
Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia
TL;DR: In this paper , the larvicidal properties of the solvent extracts from three aromatic plants, Curcuma longa (turmeric), Ocimum americanum (hoary basil), and Petroselinum crispum (parsley), against the mosquito vector of dengue, Aedes albopictus were evaluated.
Journal ArticleDOI
Potential medicinal plants to combat viral infections: A way forward to environmental biotechnology
Rhydum Sharma,Monika Bhattu,Ashutosh Tripathi,Meenakshi Verma,Roberto Acevedo,Pradeep Kumar,Vishnu D. Rajput,Jagpreet Singh +7 more
TL;DR: In this paper , a review of the emerging areas in the field of medicinal plants and their antiviral activity was done using VOS Viewer shedding light on the emerging topics in the medical field.
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