Patent
Monoclonal antibodies recognizing tie-receptor and their use
TLDR
In this paper, the anti-Tie monoclonal antibodies are described and 3C4C7G6 is provided, as well as the hybridocma cell line (DSM ACC2159).Abstract:
Novel antibodies, which are reactive with Tie, a receptor tyrosine kinase found in endothelial cells and in certain tumor cell populations are described. Anti-Tie monoclonal antibodies are described and the monoclonal antibody 3C4C7G6 is provided, as well as the hybridocma cell line (DSM ACC2159) which produces it. The antibodies are useful as diagnostic tools for detecting neoplastic diseases involving tumor angiogenesis, wound healing and a variety of other angiogenesis associated diseases and for radiological imaging of blood vessels. In addition, the disclosed antibodies are useful as therapeutic agents.read more
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Patent
Tie-2 ligands, methods of making and uses thereof
Samuel Davis,Joanne Bruno,Mitchell Goldfarb,Aldrich Thomas H,Maisonpierre Peter C,Czeslaw Radziejewski,Pamela F. Jones,George D. Yancopoulos +7 more
TL;DR: In this article, an isolated nucleic acid molecule encoding a human TIE-2 ligand was provided for a receptor body which specifically binds a human TL ligand and an antibody which specifically bind a human IL 2 ligand.
Patent
Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof
Kari Alitalo,Vladimir Joukov +1 more
TL;DR: In this paper, the authors provided a list of VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4-RHTK-3.
Patent
TIE ligand homologues
J. Paul Burlingame Godowski,L. Austin Belmont Gurney,Kenneth San Francisco Hillan,David Botstein,Audrey San Francisco Goddard,Margaret San Francisco Roy,Napoleone Ferrara,Daniel Orinda Tumas,Ralph Pacifica Schwall +8 more
TL;DR: In this paper, isolated nucleic acid molecules encoding the TIE ligands NL1, NL5, NL8 and NL4, the proteins encoded by such nucleic acids molecules, as well as methods and means for making and using such NCA and protein molecules are described.
Patent
Tie2 antagonist antibodies
TL;DR: Tie2 receptor antagonist antibodies, their use in inhibiting angiogenesis and other uses are disclosed in this article, where they are used in a variety of applications, including:
Patent
Tie2 agonist antibodies
TL;DR: Tie2 receptor agonist antibodies, their use in enhancing angiogenesis and other uses are disclosed in this article, where the use of ligand-2 receptors is discussed.
References
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Journal ArticleDOI
Humanization of a mouse monoclonal antibody by CDR-grafting: the importance of framework residues on loop conformation.
Catherine A. Kettleborough,Jose Saldanha,Victoria J. Heath,Charlotte J. Morrison,Mary M. Bendig +4 more
TL;DR: The different versions of 425-reshaped human antibody showed a wide range of avidities for antigen, indicating that substitutions at certain positions in the human FRs significantly influenced binding to antigen.
Journal ArticleDOI
A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.
Juha Partanen,Elina Armstrong,Tomi P. Mäkelä,Jaana Korhonen,M Sandberg,Risto Renkonen,Sakari Knuutila,K Huebner,Kari Alitalo +8 more
TL;DR: The cloning and characterization of tie is described, a novel type of human endothelial cell surface receptor tyrosine kinase that may have evolved for multiple protein-protein interactions, possibly including cell adhesion to the vascular endothelium.
Patent
Tie, a novel endothelial cell receptor tyrosine kinase
TL;DR: In this article, the cloning, sequencing and expression of a novel receptor tyrosine kinase, termed tie, is described, and the tie precursor comprises 1138 amino acid residues, about 1117 residues of which comprise the mature tie.