Journal ArticleDOI
Morphologic and endocrine aspects of prostatic function
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TLDR
This review focuses on prostatic secretion, its normal postnatal development, and its functional and possible regulatory significance and an hypothesis is presented on the interdependence of secretion and cell proliferation in the prostate.Abstract:
Current topics on the normal anatomy and functional organization of the human prostate are presented and related to endocrine principles studied experimentally in dogs and rats. While detailed internal organization and gross anatomical structure of the human gland are still debated by some, there is considerable unanimity on the functional interdependence and relationship between the stroma and the epithelium, as has been concluded from experimental, embryological, and pathological observations. This review also focuses on prostatic secretion, its normal postnatal development, and its functional and possible regulatory significance. Secretion is closely related to both hormonal and neurovascular regulatory mechanisms, and any changes in their balance evoke characteristic, and in some instances species-specific, morphological and functional reactions in the prostate. An hypothesis is presented on the interdependence of secretion and cell proliferation in the prostate.read more
Citations
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Journal ArticleDOI
Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: a stem cell model.
Helmut Bonkhoff,Klaus Remberger +1 more
TL;DR: A stem cell model is presented for the organization of the prostatic epithelium that may explain normal and abnormal growth in the human prostate and the majority of exocrine tumor cells are androgen‐responsive in contrast to endocrine differentiated cell types that consistently lack the nuclear androgen receptor (AR).
Journal ArticleDOI
Androgen receptor localization in different cell types of the adult rat prostate.
TL;DR: Findings indicate a complex pattern of AR expression among different cell types of the three prostate lobes, whereas cells types that express AR can potentially be considered as direct targets of androgen action, whereas those lacking AR should be consider as indirect targets or androgen-insensitive cells.
Journal ArticleDOI
Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1
TL;DR: The development and characterization of an epithelial cell line (BPH-1) from human prostate tissue obtained by transurethral resection, which expresses the SV40 large T antigen and exhibits increased levels of p53, as determined by immunocytochemistry.
Journal ArticleDOI
The proliferative function of basal cells in the normal and hyperplastic human prostate.
TL;DR: The immunoprofile of three well‐characterized proliferation‐associated antigens (Ki‐67, PCNA, MIB 1) in normal and hyperplastic prostate tissue studied suggests that the proliferative compartment of the normal andhyperplastic epithelium is located in the basal cell layer.
Journal ArticleDOI
Prostate cancer stem cells.
TL;DR: Although still controversial, the cancer stem cell is likely to be the most crucial target in the treatment of prostate cancer, and a thorough understanding of its biology might allow it to be targeted selectively and eliminated, thus improving therapeutic outcome.
References
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Journal ArticleDOI
The zonal anatomy of the prostate
TL;DR: Four basic anatomic regions of the prostate are described, using a three‐dimensional model, and marked histologic differences between central and peripheral zones suggest important biologic differences.
Journal ArticleDOI
The induction of prostatic hypertrophy in the dog with androstanediol.
P. C. Walsh,J. D. Wilson +1 more
TL;DR: The effects of androstanediol and estradiol on prostatic growth were investigated in castrate dogs and it is possible that they are involved in the pathogenesis of prostatic hypertrophy in the dog.