S
Simon W. Hayward
Researcher at NorthShore University HealthSystem
Publications - 195
Citations - 14157
Simon W. Hayward is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Prostate cancer & Stromal cell. The author has an hindex of 61, co-authored 191 publications receiving 13131 citations. Previous affiliations of Simon W. Hayward include Meharry Medical College & Monroe Carell Jr. Children's Hospital at Vanderbilt.
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Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Robert E. Chapin,Jane Adams,Kim Boekelheide,L. Earl Gray,Simon W. Hayward,Peter S.J. Lees,Barry S. McIntyre,Kenneth M. Portier,Teresa M. Schnorr,Sherry G. Selevan,John G. Vandenbergh,Susan Woskie +11 more
TL;DR: This research presents a meta-analyses of the immune system’s response to exposure to radiation and shows clear patterns of decline in the immune systems of men and women aged 65 and over.
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Role of the stromal microenvironment in carcinogenesis of the prostate.
TL;DR: The goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malignant prostatic growth to emphasize the role of the stromal microenvironment in the carcinogenic process.
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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin
Begum Erdogan,Mingfang Ao,Lauren M. White,Anna L. Means,Bryson M. Brewer,Lijie Yang,M. Kay Washington,Chanjuan Shi,Omar E. Franco,Omar E. Franco,Alissa M. Weaver,Simon W. Hayward,Simon W. Hayward,Deyu Li,Donna J. Webb +14 more
TL;DR: It is shown that fibronectin (Fn) assembled by CAFs mediates CAF–cancer cell association and directional migration, and it is demonstrated that aligned Fn is a prominent feature of invasion sites in human prostatic and pancreatic carcinoma samples.
Journal ArticleDOI
Cancer associated fibroblasts in cancer pathogenesis
TL;DR: Current trends in the study of the interactions between cancer stroma and tumor cells in different organs are addressed to highlight perceived knowledge gaps and suggest research areas that need to be further explored to provide new targets for anticancer therapies.