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Journal ArticleDOI

Mouse osteoblasts synthesize collagenase in response to bone resorbing agents

Joan K. Heath, +3 more
- 06 Nov 1984 - 
- Vol. 802, Iss: 1, pp 151-154
TLDR
Bone cells isolated from mouse calvariae by a sequential digestion procedure have many osteoblast characteristics, but in confluent monolayer culture they do not secrete collagenase in appreciable quantities, unless stimulated with resorptive substances.
About: 
This article is published in Biochimica et Biophysica Acta.The article was published on 1984-11-06. It has received 187 citations till now. The article focuses on the topics: Bone cell & Osteoblast.

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Citations
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Journal ArticleDOI

Skeletal Effects of Estrogen

Russell T. Turner, +2 more
- 01 Jun 1994 - 
TL;DR: Estrogen appears to be the most important sex steroid in preventing osteoporosis in women and is the subject of this review.
Journal ArticleDOI

Concepts of Osteoblast Growth and Differentiation: Basis for Modulation of Bone Cell Development and Tissue Formation:

Jane B. Lian, +1 more
- 01 Jan 1992 - 
TL;DR: It is found that oncogene expression in proliferating osteoblasts contributes to the suppression of genes expressed postproliferatively, and that chromatin structure and the presence of nucleosomes contribute to three-dimensional organization of gene promoters that support synergistic and/or antagonistic activities of physiologic mediators of bone cell growth and differentiation.
Journal ArticleDOI

Bone cell biology: the regulation of development structure, and function in the skeleton

Sandy C. Marks, +1 more
- 01 Sep 1988 - 
TL;DR: Any understanding of bone cell regulation is a key ingredient in understanding not only the development, maintenance, and repair of the skeleton but also the prevention and treatment of skeletal disorders.
Journal ArticleDOI

Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria : Association of MMP induction with bone resorption

Kenichiro Kusano, +7 more
- 01 Mar 1998 - 
TL;DR: The potency of induction of MMPs by IL-1 and IL-6 is closely linked to the respective bone-resorbing activity, suggesting that MMP-dependent degradation of bone matrix plays a key role in bone resorption induced by these cytokines.
Journal ArticleDOI

Osteoblast-Like Cells in the Presence of Parathyroid Hormone Release Soluble Factor that Stimulates Osteoclastic Bone Resorption

P. M. J. McSHEEHY, +1 more
- 01 Oct 1986 - 
TL;DR: Investigations into the mechanism by which osteoblastic cells stimulate osteoclasts found that increased resorption could not be accounted for by changes in the bone substrate, suggesting that PTH acts primarily on osteoblasts.
References
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Journal ArticleDOI

Maturation of the head of bacteriophage T4. I. DNA packaging events.

Ulrich K. Laemmli, +1 more
- 15 Nov 1973 - 
TL;DR: Pulse-chase experiments in wild-type and mutant phage-infected cells provide evidence that the following particles called prohead I, II and III are successive precursors to the mature heads as discussed by the authors.
Journal ArticleDOI

A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Barry L. Brown, +3 more
- 01 Feb 1971 - 
Journal ArticleDOI

An interleukin 1 like factor stimulates bone resorption in vitro.

Maxine Gowen, +4 more
- 24 Nov 1983 - 
TL;DR: To determine whether purified IL-1 could stimulate connective tissue breakdown in vitro, preliminary experiments with monocyte-conditioned medium indicated that MCF could stimulate bone resorption, and this study undertook this study to verify these observations.
Journal ArticleDOI

Role of osteoblasts in hormonal control of bone resorption - a hypothesis

Gideon A. Rodan, +1 more
- 01 Jan 1981 - 
TL;DR: The following hypothesis attempts to explain the puzzling fact that osteoblasts--the bone-forming cells--seem to be the target cells of parathyroid hormone (PTH), the prostaglandins, and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the bone-resorbing hormones.
Journal ArticleDOI

Biochemical Characterization with Parathormone and Calcitonin of Isolated Bone Cells: Provisional Identification of Osteoclasts and Osteoblasts

Richard A. Luben, +2 more
- 01 Aug 1976 - 
TL;DR: Two metabolically distinct types of bone cell populations were isolated from mouse calvaria by a repetitive digestive procedure with a mixture of collagenase and trypsin, and it is postulate that the CT type of populations is enriched in osteoclasts and, possibly, osteocytes, and the PT type of population is enrichment in osteoblasts.
Related Papers (5)

Role of osteoblasts in hormonal control of bone resorption - a hypothesis

Gideon A. Rodan, +1 more
- 01 Jan 1981 - 

Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact.

T.J. Chambers, +1 more
- 01 Jun 1985 - 

The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones.

T. J. Chambers, +3 more
- 01 Jan 1985 - 

Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone.

P. M. J. McSHEEHY, +1 more
- 01 Feb 1986 - 

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation.

Yves Eeckhout, +1 more
- 15 Jul 1977 -Â