Journal ArticleDOI
Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches.
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TLDR
The challenges for the clinical detection of MDR will be to find new biomarkers and to determine new evaluation systems before the drug resistance emerges, which will likely combine the existing therapies with drugs originated from MDR mechanisms.About:
This article is published in Cancer Letters.The article was published on 2014-06-01. It has received 537 citations till now.read more
Citations
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Mechanisms of Multidrug Resistance in Cancer Chemotherapy.
TL;DR: The aim of this review is to demonstrate the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment but also to present the mechanism of action of novel potential antitumor drugs which have been designed to overcome these resistance mechanisms.
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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade.
Zhaolin Chen,Tianlu Shi,Lei Zhang,Pengli Zhu,Mingying Deng,Cheng Huang,Tingting Hu,Ling Jiang,Jun Li +8 more
TL;DR: Recent findings suggest that efflux pumps of the ABC transporter family are subject to epigenetic gene regulation, and this review summarizes recent findings of the role of ABC efflux transporters in MDR.
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Drug resistance and combating drug resistance in cancer
TL;DR: The complexity of drug resistance development suggests that combinational and personalized therapies, which should take ATP into consideration, might provide better strategies and improved efficacy for fighting drug resistance in cancer.
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Nanomaterials for cancer therapy: current progress and perspectives.
TL;DR: Nanomaterials are materials in the nanorange 1-100nm which possess unique optical, magnetic, and electrical properties as discussed by the authors, and they have been modified for a wide range of cancer therapies to overcome toxicity and lack of specificity.
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Nanotechnology for Cancer Therapy Based on Chemotherapy.
TL;DR: To achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment.
References
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Journal ArticleDOI
The Human ATP-Binding Cassette (ABC) Transporter Superfamily
TL;DR: The current knowledge of the human ABC genes, their role in inherited disease, and understanding of the topology of these genes within the membrane are reviewed.
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miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells.
TL;DR: The findings suggest that miR‐15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2.
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P-glycoprotein: multidrug-resistance and a superfamily of membrane-associated transport proteins.
TL;DR: It now appears that Pgp‐mediated MDR tumor cells do occur in human cancers, and that they are likely to play a role in the ultimate response of patients to chemotherapy.
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Chemotherapy-induced resistance by ATP-binding cassette transporter genes.
TL;DR: This review emphasizes the involvement of ABC transporters in resistance to chemotherapy, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABCtransporters.