Journal ArticleDOI
Multicomponent Reactions for the Synthesis of Bioactive Compounds: A Review
TLDR
The aim of this review is to present the main multicomponent reactions since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their significance in the discovery of new bioactive compounds.Abstract:
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final product has all or most of the carbon atoms from its starting materials. These reactions represent, in the medicinal chemistry context, great potential in the research for new bioactive compounds, since their products can present great structural complexity. The aim of this review is to present the main multicomponent reactions since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their significance in the discovery of new bioactive compounds. The use of MCRs is, indeed, a growing field of interest in the synthesis of bioactive compounds and approved drugs, with several examples of commerciallyavailable drugs that are (or can be) obtained through these protocols.read more
Citations
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The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules.
TL;DR: In this article, the most promising scaffolds in what concerns their drug-like properties were evaluated by evaluating their compliance with some of the most valuable rules applied by medicinal chemists in both academia and industrial settings.
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Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions.
TL;DR: This review presents several illustrative applications of the use of sustainable protocols in the synthesis of organic compounds under solvent-free reaction conditions.
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Dual active 1, 4-dihydropyridine derivatives: Design, green synthesis and in vitro anti-cancer and anti-oxidant studies.
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An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety.
Renzo Rossi,Maurizio Ciofalo +1 more
TL;DR: In this review, significant attention was paid to summarise the strategies used to overcome the antibiotic resistance of pathogens whose infections are difficult to treat with conventional antibiotics, but this review does not include literature data on the synthesis and evaluation of the bioactivity of hybrids and conjugates in which an imidazole moiety is fused with a carbo- or heterocyclic subunit.
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Green Chemistry and Coronavirus.
Sepideh Ahmadi,Navid Rabiee,Yousef Fatahi,Seyyed Emad Hooshmand,Mojtaba Bagherzadeh,Mohammad Rabiee,Vahid Jajarmi,Rassoul Dinarvand,Sajjad Habibzadeh,Mohammad Reza Saeb,Rajender S. Varma,Mohammadreza Shokouhimehr,Michael R. Hamblin +12 more
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References
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
Journal ArticleDOI
Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
Journal ArticleDOI
Asymmetric multicomponent reactions (amcrs): the new frontier
Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
Journal ArticleDOI
Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.
TL;DR: This review highlights recent developments in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones with a focus on the DHPMs recently developed as calcium channel modulators, alpha(1a) adrenoceptor-selective antagonists and compounds that target the mitotic machinery.
Journal ArticleDOI
Multiple-Component Condensation Strategies for Combinatorial Library Synthesis
TL;DR: This Account focuses on multiple-component condensations (MCCs) as one subset of strategies for the generation of compound libraries, and it is instructive to contrast this approach with linear synthesis to highlight the differences in methods, potential library size, and output format.
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