Journal ArticleDOI
Multiple dopamine receptors and behavior.
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TLDR
It is unlikely that the atypical antipsychotics and antiparkinsonian agents interact with only one subtype of DA receptor, or have their therapeutic actions only through that receptor, and other pharmacological characteristics of these agents are more critically involved in their unique behavioral effects.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1983-06-01. It has received 114 citations till now. The article focuses on the topics: Antiparkinsonian Agent & Dopamine receptor.read more
Citations
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Journal ArticleDOI
Dopamine and sexual behavior.
TL;DR: Evidence is provided that dopamine through its different neuronal systems and receptor subtypes plays different roles in the control of several aspects of sexual behavior, supporting a facilitatory role of dopamine in male sexual behavior.
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Modulation of brain dopamine transmission by sex steroids.
TL;DR: A better understanding of steroid-dopamine interactions and the possible isolation of conditions to have only pro or anti dopaminergic activity could then be used to develop combined therapies or to optimize drug treatments that would take into account the patient's sex and endocrine status.
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Dopamine and the structure of personality: relation of agonist-induced dopamine activity to positive emotionality.
TL;DR: The results suggest that the trait structure of personality may be related to individual differences in brain DA functioning, and specifically associated with trait levels of PE, but not with other personality traits.
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Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: evidence for D1 receptor involvement.
TL;DR: It is concluded that the inhibitory effect of dopamine on rat striatal neurons is postsynaptically mediated by the activation of D1 dopaminergic receptors via the reduction of a voltage-dependent tetrodotoxin-sensitive inward conductance.
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Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs.
TL;DR: Because of distinct aspects of regulation of the D3 receptor, it represents a unique target for therapeutic intervention in schizophrenia without high potential for unintended side effects such as tardive dyskinesia.
References
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Journal ArticleDOI
Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
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Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
TL;DR: A clinical, morphological and neurochemical correlative study in patients with Parkinson's syndrome and Huntington's chorea is reported in this paper, where positive correlations can be established, within a certain range, between the severity of individual Parkinsonian symptoms (especially akinesia and tremor) and the degree, and also the site, of the disturbance of dopamine metabolism within the nuclei of the basal ganglia; and the sensitivity of the patients to levodopa's acute anti-akinesia effect.
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From motivation to action: functional interface between the limbic system and the motor system
TL;DR: It has been proposed that the nucleus accumbens is a key component of this neural interface since it receives inputs from limbic forebrain structures, either directly or indirectly via the ventral tegmental area of Tsai, and sends signals to the motor system via the globus pallidus.
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
TL;DR: Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
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Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
TL;DR: In this article, the effect of L-DOPA and the dopamine receptor stimulating drug apomorphine was studied in rats after unilateral degeneration of the nigrostriatal DA system by intracerebral injection of 6-hydroxydopamine.