Journal ArticleDOI
Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TLDR
Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.Abstract:
Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.read more
Citations
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Journal ArticleDOI
Dopamine Receptors: From Structure to Function
TL;DR: Target deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions and provide unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disorders.
Journal ArticleDOI
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
Charles R. Gerfen,Thomas M. Engber,Lawrence C. Mahan,Zvi Susel,Thomas N. Chase,Frederick J. Monsma,David R. Sibley +6 more
TL;DR: The differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively.
Journal ArticleDOI
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
TL;DR: The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions, and seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease.
Journal ArticleDOI
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
TL;DR: D dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms are discussed.
Journal ArticleDOI
Dopamine in Schizophrenia: A Review and Reconceptualization
TL;DR: The authors hypothesize that schizophrenia is characterized by abnormally low prefrontal dopamine activity leading to excessive dopamine activity in mesolimbic dopamine neurons (causing positive symptoms) and has important implications for treatment of schizophrenia and schizophrenia spectrum disorders.
References
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Journal ArticleDOI
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
TL;DR: Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
Psychopharmacology : a generation of progress
TL;DR: This all-encompassing volume was developed by the American College of Neuropsychopharmacology for the purpose of providing a comprehensive survey of progress in that field, and covers the ethics of the use of the drugs, their biochemical bases, and their clinical utilization.
Journal ArticleDOI
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”
TL;DR: The results suggest that dopamine-sensitive adenylate cyclase may be the receptor for dopamine in mammalian brain and should facilitate the search for new therapeutic agents useful in the treatment of extrapyramidal diseases.
Journal ArticleDOI
The central effects of a novel dopamine agonist.
TL;DR: The results suggest that SK & F 38393 may selectively stimulate supersensitive central dopamine receptors in vivo or may activate only a certain subclass of dopamine receptors including the receptor in the renal vasculature and the adenylate cyclase coupled postsynaptic receptors in the caudate.
Journal ArticleDOI
Dopamine"autoreceptors": pharmacological characterization by microiontophoretic single cell recording studies.
TL;DR: Results show that DA-sensitive receptors on the soma of DA neurons are pharmacologically distinct from α or β adrenoreceptors, and appear best classified as DA “autoreceptor”.