Journal ArticleDOI
Mutational dynamics of microsatellites.
Atul Bhargava,Francisco Fuentes +1 more
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The present review focuses on the mutational dynamics of microsatellites with special reference to mutational mechanisms and their role in microsatellite evolution.Abstract:
Microsatellites are a ubiquitous class of simple repetitive DNA sequences, which are widespread in both eukaryotic and prokaryotic genomes. The use of microsatellites as polymorphic DNA markers has considerably increased both in the number of studies and in the number of organisms, primarily for genetic mapping, studying genomic instability in cancer, population genetics, forensics, conservation biology, molecular anthropology and in the studies of human evolutionary history. Although simple sequence repeats have been extensively used in studies encompassing varied areas of genetics, the mutation dynamics of these genome regions is still not well understood. The present review focuses on the mutational dynamics of microsatellite DNA with special reference to mutational mechanisms and their role in microsatellite evolution.read more
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Journal ArticleDOI
Challenges in analysis and interpretation of microsatellite data for population genetic studies
TL;DR: This review assists with study design and molecular marker selection, facilitates sound interpretation of microsatellite data while fostering respect for their practical limitations, and identifies lessons that could be applied toward emerging markers and high-throughput technologies in population genetics.
Journal ArticleDOI
Directional genetic differentiation and relative migration
TL;DR: A new simpler and more efficient approach for understanding gene flow patterns is presented that allows the estimation of directional components of genetic divergence between pairs of populations at low computational effort, using any of the classical or modern measures of genetic differentiation.
Journal ArticleDOI
Estimating genomic diversity and population differentiation – an empirical comparison of microsatellite and SNP variation in Arabidopsis halleri
Martin C. Fischer,Christian Rellstab,Marianne Leuzinger,Marie Roumet,Felix Gugerli,Kentaro Shimizu,Rolf Holderegger,Alex Widmer +7 more
TL;DR: It is inferred that a few thousand random SNPs are sufficient to reliably estimate genome-wide diversity and to distinguish among populations differing in genetic variation and recommended that future analyses of genetic diversity within and differentiation among populations use randomly selected high-throughput sequencing-based SNP data.
Journal ArticleDOI
Relative effects of road mortality and decreased connectivity on population genetic diversity
Nathan D. Jackson,Lenore Fahrig +1 more
TL;DR: The genetic effects of road-mediated mortality have been underappreciated and should be more often considered before prioritizing road-mitigation measures, and it is shown that the vast majority of potential variation in genetic diversity is governed by depletion rather than barrier effects.
Journal ArticleDOI
Directional genetic differentiation and asymmetric migration
TL;DR: DivMigrate-online as mentioned in this paper is a web application that allows the estimation of directional components of genetic divergence between pairs of populations at low computational effort, using any of the classical or modern measures of genetic differentiation, which can further be used to calculate directional relative migration and to detect asymmetries in gene flow patterns.
References
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Journal ArticleDOI
An Introduction to Population Genetics Theory
James F. Crow,Motoo Kimura +1 more
TL;DR: An introduction to population genetics theory, An introduction to Population Genetics Theory, Population Genetics theory, Population genetics theory as discussed by the authors, Population genetics, population genetics, and population genetics theories, Population Genetic Theory
Book
An introduction to population genetics theory
James F. Crow,Motoo Kimura +1 more
TL;DR: An introduction to population genetics theory, An introduction to Population Genetics theory, and more.
Journal ArticleDOI
A measure of population subdivision based on microsatellite allele frequencies.
TL;DR: It was found that, under the generalized stepwise mutation model, R( ST) provides relatively unbiased estimates of migration rates and times of population divergence while F(ST) tends to show too much population similarity, particularly when migration rates are low or divergence times are long.
Journal ArticleDOI
The Number of Alleles That Can Be Maintained in a Finite Population
Motoo Kimura,James F. Crow +1 more
TL;DR: This article proposes to examine some of the population consequences of a system of different isoalleles whose frequency in the population is determined by the mutation rate and by random drift, and considers three possibilities: A system of selectively neutral isoallels, a systemof mutually heterotic alleles, and a mixture of heterotic and harmful mutants.
Journal ArticleDOI
Slipped-strand mispairing: a major mechanism for DNA sequence evolution.
G Levinson,George A. Gutman +1 more
TL;DR: Evidence is presented that single-base repeats (the shortest possible motifs) are represented by longer runs in mammalian introns than would be expected on a random basis, supporting the idea that SSM may be a ubiquitous force in the evolution of the eukaryotic genome.
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