Journal ArticleDOI
Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
Markus Schuelke,Kathryn R. Wagner,Leslie E Stolz,Christoph Hübner,Thomas Riebel,Wolfgang Kömen,Thomas Braun,James F. Tobin,Se-Jin Lee +8 more
TLDR
A mutation in the gene for myostatin is described in a child with muscle hypertrophy and unusual strength and greater understanding of muscle growth and maintenance is important for future therapies.Abstract:
Both acquired and inherited disorders of muscle are common; thus, greater understanding of muscle growth and maintenance is important for future therapies. Myostatin down-regulates muscle growth. These investigators describe a mutation in the gene for myostatin in a child with muscle hypertrophy and unusual strength.read more
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A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
Alex Clop,Fabienne Marcq,Haruko Takeda,Dimitri Pirottin,Xavier Tordoir,Bernard Bibé,Jacques Bouix,Florian Caiment,Jean-Michel Elsen,F. Eychenne,Catherine Larzul,Elisabeth Laville,Françoise Meish,Dragan Milenkovic,James Tobin,Carole Charlier,Michel Georges +16 more
TL;DR: It is demonstrated that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3′ UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle that causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy ofTexel sheep.
Journal ArticleDOI
Cellular and molecular mechanisms of muscle atrophy
Paolo Bonaldo,Marco Sandri +1 more
TL;DR: This paper reviews the key mechanisms that regulate the turnover of contractile proteins and organelles in muscle tissue, and discusses how impairments in these mechanisms can contribute to muscle atrophy.
Journal ArticleDOI
Cancer cachexia: mediators, signaling, and metabolic pathways.
TL;DR: Progress in understanding conserved, molecular mechanisms of skeletal muscle atrophy/hypertrophy has provided a downstream platform for circumventing the variations and redundancy in upstream mediators and may ultimately translate into new targeted therapies.
Journal ArticleDOI
Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives
Yves Rolland,Stefan A. Czerwinski,G. Abellan Van Kan,John E. Morley,Matteo Cesari,Graziano Onder,Jean Woo,Richard N. Baumgartner,Fabien Pillard,Yves Boirie,Wm. Cameron Chumlea,Bruno Vellas +11 more
TL;DR: On-going and future clinical trials on sarcopenia may radically change the authors' preventive and therapeutic approaches of mobility disability in older people.
Journal ArticleDOI
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Xiaolan Zhou,Jin Lin Wang,John Lu,Yanping Song,Keith S. Kwak,Qingsheng Jiao,Robert Rosenfeld,Qing Chen,Thomas Boone,W. Scott Simonet,David L. Lacey,Alfred L. Goldberg,Hq Han +12 more
TL;DR: It is shown that in several cancer cachexia models, pharmacological blockade of ActRIIB pathway not only prevents further muscle wasting but also completely reverses prior loss of skeletal muscle and cancer-induced cardiac atrophy, establishing a crucial link between activation of the ActR IIB pathway and the development of cancer Cachexia.
References
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