Journal ArticleDOI
N-acetyl cysteine treatment mitigates biomarkers of oxidative stress in different tissues of bile duct ligated rats.
Mohammad Mehdi Ommati,Ali Amjadinia,Khadijeh Mousavi,Negar Azarpira,Akram Jamshidzadeh,Reza Heidari +5 more
TLDR
It was found that NAC treatment significantly mitigated biomarkers of oxidative stress and alleviated tissue histopathological changes in cirrhotic rats, representing NAC as a potential protective agent with therapeutic capability in cholestasis and its associated complications.Abstract:
Cholestasis is a multifaceted clinical complication. Obstructive jaundice induced by bile duct ligation (BDL) is known as an animal model to investigate cholestasis and its associated complications...read more
Citations
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Journal ArticleDOI
Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia.
TL;DR: In this article, Parkin-independent mitophagy was found to converge to eliminate oxidation-damaged mitochondria by the ubiquitin-proteasome system and receptor-mediated autophagy.
Journal ArticleDOI
The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity.
Asrin Ahmadi,Hossein Niknahad,Huifeng Li,Ali Mobasheri,Ram Kumar Manthari,Negar Azarpira,Khadijeh Mousavi,Bahman Khalvati,Yangfei Zhao,Jianyu Sun,Yuqi Zong,Mohammad Mehdi Ommati,Mohammad Mehdi Ommati,Reza Heidari +13 more
TL;DR: In this paper, the role of nuclear factor-kB (NFkB)-mediated inflammatory response is investigated in an animal model of cholestasis, where Bile duct ligated (BDL) animals were treated with sulfasalazine (SSLZ, 10 and 100 mg/kg, i.p) as a potent inhibitor of NFkB signaling.
Journal ArticleDOI
Agmatine alleviates hepatic and renal injury in a rat model of obstructive jaundice
Mohammad Mehdi Ommati,Omid Farshad,Khadijeh Mousavi,Rasool Taghavi,Saeed Farajvajari,Negar Azarpira,Leila Moezi,Reza Heidari +7 more
TL;DR: It was found that agmatine supplementation significantly alleviated cholestasis-induced hepatic and renal injury and its mechanism of action could be related to its antioxidant properties and the positive effects of this amine on mitochondrial indices.
Journal ArticleDOI
The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics
Mohammad Mehdi Ommati,Huifeng Li,Akram Jamshidzadeh,Fereshteh Khoshghadam,Socorro Retana-Márquez,Yu Cheng Lu,Omid Farshad,Mohammad Hasan Nategh Ahmadi,Ahmad Gholami,Reza Heidari +9 more
TL;DR: Findings indicate that the indigenous yogurt-isolated/cultured probiotics had a high potential antioxidant activity and the ameliorative effect against reprotoxicity and blood biochemical alterations induced by the NAFLD model.
Journal ArticleDOI
Taurine mitigates bile duct obstruction-associated cholemic nephropathy: effect on oxidative stress and mitochondrial parameters
TL;DR: In this paper, the authors evaluated the impact of Taurine (TAU) on the kidney of cholestasis-induced organ injury in Bile duct ligated (BDL) rats.
References
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Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Journal ArticleDOI
Phagocytes and oxidative stress
TL;DR: A large number of highly reactive microbicidal oxidants are formed, including HOCl (hypochlorous acid), which is produced by the myeloperoxidase-catalyzed oxidation of Cl(-) by H(2)O(2); OH(*) (hydroxyl radical); ONOO(-) (peroxynitrite), formed by the reaction between O(2)(-) and NO(*); and many others.
Journal ArticleDOI
Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer
TL;DR: The antioxidant defense systems, free radicals production and their role in cancer and age related diseases and also some of the recent patent relevant to the field are reviewed.
Journal ArticleDOI
Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
Gustav Paumgartner,Ulrich Beuers +1 more
TL;DR: Experimental evidence suggests three major mechanisms of action of UDCA, which may improve serum liver chemistries, delay disease progression to severe fibrosis or cirrhosis, and may prolong transplant‐free survival in primary biliary Cirrhosis and primary sclerosing cholangitis.
Journal ArticleDOI
The chemistry and biological activities of N-acetylcysteine
TL;DR: The present review is focused on the chemistry of NAC and its interactions and functions at the organ, tissue and cellular levels in an attempt to bridge the gap between its recognized biological activities and chemistry.
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The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis.
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