Journal ArticleDOI
Agmatine alleviates hepatic and renal injury in a rat model of obstructive jaundice
Mohammad Mehdi Ommati,Omid Farshad,Khadijeh Mousavi,Rasool Taghavi,Saeed Farajvajari,Negar Azarpira,Leila Moezi,Reza Heidari +7 more
TLDR
It was found that agmatine supplementation significantly alleviated cholestasis-induced hepatic and renal injury and its mechanism of action could be related to its antioxidant properties and the positive effects of this amine on mitochondrial indices.About:
This article is published in PharmaNutrition.The article was published on 2020-09-01. It has received 20 citations till now. The article focuses on the topics: Agmatine & Kidney.read more
Citations
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Changes in Glutathione Content in Liver Diseases: An Update
Mariapia Vairetti,Laura Giuseppina Di Pasqua,Marta Cagna,Plinio Richelmi,Andrea Ferrigno,Clarissa Berardo +5 more
TL;DR: The multiple GSH functions will be described, as well as the importance of GSH compartmentalization into distinct subcellular pools and inter-organ transfer, and the close relationship existing between GSH content and the pathogenesis of liver disease, such as non-alcoholic fatty liver disease (NAFLD, alcoholic liver disease) and chronic cholestatic injury.
Journal ArticleDOI
The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity.
Asrin Ahmadi,Hossein Niknahad,Huifeng Li,Ali Mobasheri,Ram Kumar Manthari,Negar Azarpira,Khadijeh Mousavi,Bahman Khalvati,Yangfei Zhao,Jianyu Sun,Yuqi Zong,Mohammad Mehdi Ommati,Mohammad Mehdi Ommati,Reza Heidari +13 more
TL;DR: In this paper, the role of nuclear factor-kB (NFkB)-mediated inflammatory response is investigated in an animal model of cholestasis, where Bile duct ligated (BDL) animals were treated with sulfasalazine (SSLZ, 10 and 100 mg/kg, i.p) as a potent inhibitor of NFkB signaling.
Journal ArticleDOI
The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics
Mohammad Mehdi Ommati,Huifeng Li,Akram Jamshidzadeh,Fereshteh Khoshghadam,Socorro Retana-Márquez,Yu Cheng Lu,Omid Farshad,Mohammad Hasan Nategh Ahmadi,Ahmad Gholami,Reza Heidari +9 more
TL;DR: Findings indicate that the indigenous yogurt-isolated/cultured probiotics had a high potential antioxidant activity and the ameliorative effect against reprotoxicity and blood biochemical alterations induced by the NAFLD model.
Journal ArticleDOI
The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice
Mohammad Mehdi Ommati,Mohammad Reza Arabnezhad,Omid Farshad,Akram Jamshidzadeh,Hossein Niknahad,Socorro Retana-Márquez,Zhipeng Jia,Mohammad Hassan Nateghahmadi,Khadijeh Mousavi,Aysooda Arazi,Mohammad Reza Azmoon,Negar Azarpira,Reza Heidari +12 more
TL;DR: In this article, the authors illustrate the mechanisms of adverse effects of Li+ on the testis tissue, spermatogenesis process, and hormonal changes in two experimental models, where mice were treated with Li+ (0, 10, 50, and 100 ppm, in drinking water) for five consecutive weeks.
Journal ArticleDOI
Apoptosis-inducing factor plays a role in the pathogenesis of hepatic and renal injury during cholestasis
Vahid Ghanbarinejad,Akram Jamshidzadeh,Bahman Khalvati,Omid Farshad,Huifeng Li,Xiong Shi,Yuanyu Chen,Mohammad Mehdi Ommati,Reza Heidari +8 more
TL;DR: In this paper, the role of AIF in the pathophysiology of cholestasis-associated hepatic and renal injury was evaluated in Bile duct ligation (BDL) rats.
References
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Related Papers (5)
The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis.
Reza Heidari,Hossein Niknahad +1 more