Journal ArticleDOI
Natural Product Hybrids as New Leads for Drug Discovery
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TLDR
This new approach seems to be very promising in the development of leads for both medicinal and agrochemical applications, as the biological activity of several new hybrids exceeds that of the parent compounds.Abstract:
Natural products play an important role in the development of drugs, especially for the treatment of infections and cancer, as well as immunosuppressive compounds. However, the number of natural products is limited, whereas millions of hybrids as combinations of parts of different natural products can be prepared. This new approach seems to be very promising in the development of leads for both medicinal and agrochemical applications, as the biological activity of several new hybrids exceeds that of the parent compounds. The advantage of this concept over a combinatorial chemistry approach is the high diversity and the inherent biological activity of the hybrids.read more
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Natural products as leads to anticancer drugs.
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Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?
TL;DR: Significant contributions from industrial and academic groups highlight the arduous but rewarding path from natural products to drugs, as well as principle modification types for natural products, which are discussed herein.
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In situ click chemistry: probing the binding landscapes of biological molecules
Sreeman K. Mamidyala,M. G. Finn +1 more
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Exploitation of marine algae: biogenic compounds for potential antifouling applications
TL;DR: In this paper, the authors discuss the successes of such research, and the future applications in the context of understanding the systems biology of micro-algae and cyanobacteria, and mainly discuss the success of this research and future applications.
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Hybrid molecules: The privileged scaffolds for various pharmaceuticals
TL;DR: A comparison of the drug potency of the hybrid molecules with their individual counterparts is discussed for quantifying the significance of the concept of molecular hybridisation.