Natural products evaluated in neuropathic pain models - a systematic review.
Jullyana S.S. Quintans,Ângelo R. Antoniolli,Jackson Roberto Guedes da Silva Almeida,Valter J. Santana-Filho,Lucindo José Quintans-Júnior,Lucindo José Quintans-Júnior +5 more
TLDR
The opioids, serotonergic and cannabinoid systems are suggested as the most promising targets for the natural products described, suggesting that these compounds are possible candidates for the treatment of chronic painful conditions, such as neuropathic pain.Abstract:
Chronic pain conditions, such as neuropathic pain, are a common problem that poses a major challenge to health-care providers due to its complex natural history, unclear aetiology and poor response towards therapy. Despite the large number of drugs available, the adherence is limited by the large range of side effects and pharmacological ineffectiveness. Thus, the search for new chemical entities that can act as promising molecules to treat chronic pain conditions has emerged. The natural products remain as the most promising sources of new chemical entities with applicability for the medical approach. Hence, we performed a systematic review analysing pre-clinical studies shown to be promising in a possible applicability in neuropathic pain. The search terms neuropathic pain, phytotherapy and medicinal plants were used to retrieve English language articles in LILACS, PUBMED and EMBASE published until 10 April 2013. From a total of 1529 articles surveyed, 28 met the inclusion and exclusion criteria established. The main chemical compounds studied were flavonoids (28%), terpenes (17%), alkaloids (14%), phenols (10%), carotenoids (10%) and others (21%). The mostly described animal models for the study of neuropathic pain included were chronic constriction injury (CCI - 32%), partial sciatic nerve ligation (PSNL - 28%), streptozotocin - induced diabetic (28%), alcoholic neuropathy (3.5%), sodium monoiodoacetate (MIA - 3.5%) and neuropathic pain induced by paclitaxel (3.5%). The opioids, serotonergic and cannabinoid systems are suggested as the most promising targets for the natural products described. Therefore, the data reviewed here suggest that these compounds are possible candidates for the treatment of chronic painful conditions, such as neuropathic pain.read more
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Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches.
Pollyana De Souza Siqueira Lima,Angélica Maria Lucchese,Heitor G. Araújo-Filho,Paula dos Passos Menezes,Adriano Antunes de Souza Araújo,Lucindo José Quintans-Júnior,Jullyana S.S. Quintans +6 more
TL;DR: This review shows strong experimental evidence that cyclodextrins improve the pharmacological properties of terpenes, and therefore need to be recognized as being possible targets for clinical use.
Journal ArticleDOI
Neuroprotective Strategies for Neurological Disorders by Natural Products: An update.
Muneeb U. Rehman,Adil Farooq Wali,Anas Ahmad,Sheeba Shakeel,Saiema Rasool,Rayeesa Ali,Shazada Mudasir Rashid,Hassan Madkhali,Majid Ahmad Ganaie,Rehan Khan +9 more
TL;DR: This review focuses on the various established activities of natural products in in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications using the available knowledge in the literature.
Journal ArticleDOI
Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with β-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
Adriana Gibara Guimarães,Marlange A. Oliveira,Rafael dos Santos Alves,Paula dos Passos Menezes,Mairim Russo Serafini,Adriano Antunes de Souza Araújo,Daniel P. Bezerra,Lucindo José Quintans Júnior +7 more
TL;DR: Evidence is produced that the encapsulation of carvacrol in β-cyclodextrin can be useful for the development of new options for pain management, as well as spontaneous and palpation-induced nociception.
Journal ArticleDOI
The Role of Flavonoids on Oxidative Stress in Epilepsy
Tâmara Coimbra Diniz,Juliane Cabral Silva,Sarah Raquel Gomes de Lima-Saraiva,Fernanda Pires Rodrigues de Almeida Ribeiro,Alessandra Gomes Marques Pacheco,Rivelilson Mendes de Freitas,Lucindo José Quintans-Júnior,Jullyana S.S. Quintans,Rosemairy Luciane Mendes,Jackson Roberto Guedes da Silva Almeida +9 more
TL;DR: There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy, specifically in the central nervous system.
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