Journal ArticleDOI
Neural control of phenotypic expression in mammalian muscle fibers.
Dirk Pette,Gerta Vrbová +1 more
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TLDR
In this paper, the authors summarized the present knowledge about the mechanisms involved in the control of the phenotypic expression of mammalian muscle fibers and discussed how the activity imposed on the muscle fibers by the motoneuron finally induces in the muscle cells the expression of those genes that define its particular phenotype.Abstract:
In this review, the present knowledge about the mechanisms involved in the control of the phenotypic expression of mammalian muscle fibers is summarized. There is a discussion as to how the activity imposed on the muscle fibers by the motoneuron finally induces in the muscle cells the expression of those genes that define its particular phenotype. The functional and molecular heterogeneity of skeletal muscle is thus defined by the existence of motor units with varied function, while the homogeneity of muscle fibers belonging to the same motor unit is yet another indication of the importance of activity in the control of gene expression of the mammalian muscle fiber.read more
Citations
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Journal ArticleDOI
Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease
TL;DR: Functional alterations of Ca(2+) handling seem to be responsible for the pathophysiological conditions seen in dystrophinopathies, Brody's disease, and malignant hyperthermia, which underline the importance of the affected molecules for correct muscle performance.
Book ChapterDOI
Cellular and molecular diversities of mammalian skeletal muscle fibers
Dirk Pette,Robert S. Staron +1 more
Journal ArticleDOI
Myosin isoforms, muscle fiber types, and transitions.
Dirk Pette,Robert S. Staron +1 more
TL;DR: The fiber population of skeletal muscles encompasses a continuum of pure and hybrid fiber types, and under certain conditions, changes can be induced in MHC isoform expression heading in the direction of either fast‐to‐slow or slow‐ to‐fast.
Journal ArticleDOI
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death.
TL;DR: The results suggest that while Myf-5 plays a crucial role in the formation of lateral sclerotome derivatives, My f-5 is dispensable for the development of skeletal muscle, perhaps because other members of the myogenic HLH family substitute for MyF-5 activity.
Book
Speech Perception By Ear and Eye: A Paradigm for Psychological Inquiry
TL;DR: In this paper, the processing of information in face-to-face communication when a speaker makes both audible and visible information available to a perceiver is discussed. But the evaluation of the information source provides information about the strength of alternative interpretations, rather than just all-or-none categorical information, as claimed by "categorical perception" theory.
References
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Journal ArticleDOI
Functional significance of cell size in spinal motoneurons
TL;DR: The present paper is concerned with the central part of the motoneuron and the significance of its size in synaptic transmission and asks whether the cell bodies (and dendrites) connected with large and small motor fibers have different functional properties which can be recognized by their discharge characteristics.
Journal ArticleDOI
Evidence for a central component of post-injury pain hypersensitivity
TL;DR: An animal model is developed where changes occur in the threshold and responsiveness of the flexor reflex following peripheral injury that are analogous to the sensory changes found in man, and shows that it in part arises from changes in the activity of the spinal cord.
Journal ArticleDOI
Physiological types and histochemical profiles in motor units of the cat gastrocnemius.
TL;DR: Intracellular stimulation of individual motoneurones ensured functional isolation of the muscle units innervated by them in pentobarbitone‐anaesthetized cats.
Journal ArticleDOI
Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits.
Journal ArticleDOI
THREE "MYOSIN ADENOSINE TRIPHOSPHATASE" SYSTEMS: THE NATURE OF THEIR pH LABILITY AND SULFHYDRYL DEPENDENCE
TL;DR: Two types of striated muscle fibers (Padykula amid Herman) can be distimiguished and these have been described as the less active type I and the more active type II fibers.