Journal ArticleDOI
Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects
TLDR
Primary toxic effects in mammals from off-target serine hydrolase inhibition include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system.Abstract:
Neuroactive insecticides are the principal means of protecting crops, people, livestock, and pets from pest insect attack and disease transmission. Currently, the four major nerve targets are acetylcholinesterase for organophosphates and methylcarbamates, the nicotinic acetylcholine receptor for neonicotinoids, the γ-aminobutyric acid receptor/chloride channel for polychlorocyclohexanes and fiproles, and the voltage-gated sodium channel for pyrethroids and dichlorodiphenyltrichloroethane. Species selectivity and acquired resistance are attributable in part to structural differences in binding subsites, receptor subunit interfaces, or transmembrane regions. Additional targets are sites in the sodium channel (indoxacarb and metaflumizone), the glutamate-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calcium-activated calcium channel (diamides). Secondary toxic effects in mammals from off-target serine hydrolase inhibition include organophosphate-induced delayed n...read more
Citations
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Journal ArticleDOI
Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
Noa Simon-Delso,Noa Simon-Delso,V. Amaral-Rogers,Luc P. Belzunces,Jean-Marc Bonmatin,Madeleine Chagnon,Craig A. Downs,Lorenzo Furlan,David W. Gibbons,Chiara Giorio,Vincenzo Girolami,Dave Goulson,David P. Kreutzweiser,Christian H. Krupke,Matthias Liess,Elizabeth Y. Long,Melanie McField,Pierre Mineau,Edward A. D. Mitchell,Christy A. Morrissey,D. A. Noome,L. Pisa,Josef Settele,John D. Stark,Andrea Tapparo,H Van Dyck,J. van Praagh,J.P. van der Sluijs,J.P. van der Sluijs,Penelope R. Whitehorn,Martin Wiemers +30 more
TL;DR: In this paper, a review of the global literature explores these risks and show a growing body of evidence that persistent, low concentrations of these insecticides pose serious risks of undesirable environmental impacts.
Journal ArticleDOI
IRAC: Mode of action classification and insecticide resistance management
Thomas C. Sparks,Ralf Nauen +1 more
TL;DR: Diversity is the spice of resistance management by chemical means and thus it provides an approach to IRM providing a straightforward means to identify potential rotation/alternation options.
Journal ArticleDOI
Insecticide Resistance in Mosquitoes: Impact, Mechanisms, and Research Directions
TL;DR: Current knowledge of the molecular mechanisms, genes, gene interactions, and gene regulation governing the development of insecticide resistance in mosquitoes is reviewed and the potential impact of the latest research findings on the basic and practical aspects of mosquito resistance research is discussed.
Journal ArticleDOI
A review of the direct and indirect effects of neonicotinoids and fipronil on vertebrate wildlife
TL;DR: Evidence presented here suggests that the systemic insecticides, neonicotinoids and fipronil, are capable of exerting direct and indirect effects on terrestrial and aquatic vertebrate wildlife, thus warranting further review of their environmental safety.
Journal ArticleDOI
Pesticide-Induced Stress in Arthropod Pests for Optimized Integrated Pest Management Programs
TL;DR: The present review mitigates this shortcoming by hierarchically exploring within an ecotoxicology framework applied to integrated pest management the myriad effects of insecticide use on arthropod pest species.
References
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Journal ArticleDOI
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
TL;DR: It is reported that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity.
Journal ArticleDOI
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more
TL;DR: The neonicotinoids have outstanding potency and systemic action for crop protection against piercing-sucking pests, and they are highly effective for flea control on cats and dogs.
Journal ArticleDOI
Overview of the Status and Global Strategy for Neonicotinoids
TL;DR: The crystal structure of the acetylcholine-binding proteins provides the theoretical foundation for designing homology models of the corresponding receptor ligand binding domains within the nAChRs, a useful basis for virtual screening of chemical libraries and rational design of novel insecticides acting on these practically relevant channels.
Journal ArticleDOI
Rotenone, Paraquat, and Parkinson’s Disease
Caroline M. Tanner,Freya Kamel,G. Webster Ross,Jane A. Hoppin,Samuel M. Goldman,Monica Korell,Connie Marras,Grace S. Bhudhikanok,Meike Kasten,Anabel R. Chade,Kathleen Comyns,Marie Richards,Cheryl Meng,Benjamin Priestley,Hubert H. Fernandez,Franca Cambi,David M. Umbach,Aaron Blair,Dale P. Sandler,J. William Langston +19 more
TL;DR: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally—those that impair mitochondrial function and those that increase oxidative stress—supporting a role for these mechanisms in PD pathophysiology.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
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Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
Noa Simon-Delso,Noa Simon-Delso,V. Amaral-Rogers,Luc P. Belzunces,Jean-Marc Bonmatin,Madeleine Chagnon,Craig A. Downs,Lorenzo Furlan,David W. Gibbons,Chiara Giorio,Vincenzo Girolami,Dave Goulson,David P. Kreutzweiser,Christian H. Krupke,Matthias Liess,Elizabeth Y. Long,Melanie McField,Pierre Mineau,Edward A. D. Mitchell,Christy A. Morrissey,D. A. Noome,L. Pisa,Josef Settele,John D. Stark,Andrea Tapparo,H Van Dyck,J. van Praagh,J.P. van der Sluijs,J.P. van der Sluijs,Penelope R. Whitehorn,Martin Wiemers +30 more