Journal ArticleDOI
Neurokinin A levels predict survival in patients with stage IV well differentiated small bowel neuroendocrine neoplasms.
Anne E. Diebold,J. Philip Boudreaux,Yi-Zarn Wang,Lowell Anthony,Ann Porter Uhlhorn,Pamela Ryan,Paris Mamikunian,Gregg Mamikunian,Eugene A. Woltering +8 more
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TLDR
Patients with midgut neuroendocrine neoplasms who have serial plasma neurokinin A levels <50 pg/mL have an excellent short-term prognosis, while patients with plasma neuro Kin A levels >50 pg /mL have a poor short- term prognosis.About:
This article is published in Surgery.The article was published on 2012-12-01. It has received 21 citations till now. The article focuses on the topics: Neurokinin A.read more
Citations
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Journal ArticleDOI
Role of biomarker tests for diagnosis of neuroendocrine tumours
TL;DR: The diagnosis of gastroenteropancreatic neuroendocrine tumours (NETs) should be made by histological evaluation of tumour tissue, as the diagnostic accuracy of current circulating and imaging biomarkers is insufficient.
Journal ArticleDOI
Prognostic and predictive biomarkers in neuroendocrine tumours.
David Chan,Stephen Clarke,Stephen Clarke,Connie I. Diakos,Connie I. Diakos,Paul Roach,Dale L. Bailey,Simron Singh,Nick Pavlakis,Nick Pavlakis +9 more
TL;DR: Blood-based markers are easily repeatable, but currently established biomarkers are difficult to measure accurately in practice and functional imaging such as 68Ga-based and FDG PET may become valuable biomarkers with their increasing availability, aided by ongoing quantitative research.
Journal ArticleDOI
Management of neuroendocrine tumors of unknown primary.
Krystallenia I Alexandraki,Anna Angelousi,Georgios Boutzios,Georgios Kyriakopoulos,Dimitra Rontogianni,Gregory Kaltsas +5 more
TL;DR: It is expected that the delineation of the molecular signature of the different NENs may help identify cases and provide appropriate treatment, as in a number of cases no lesion is identified even after prolonged follow-up.
Journal ArticleDOI
Biochemical Diagnosis and Preoperative Imaging of Gastroenteropancreatic Neuroendocrine Tumors.
TL;DR: The biomarkers important for the diagnosis of neuroendocrine tumors and the imaging modalities needed are discussed.
Journal ArticleDOI
DcR3, TFF3, and Midkine Are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors
Katarina Edfeldt,Kosmas Daskalakis,Christofer Bäcklin,Olov Norlén,Eva Tiensuu Janson,Gunnar Westin,Per Hellman,Peter Stålberg +7 more
TL;DR: DcR3 seems to be a marker for liver metastases, while TFF3 and midkine may be new diagnostic biomarkers for SI-NETs.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
The NANETS Consensus Guideline for the Diagnosis and Management of Neuroendocrine Tumors Well-Differentiated Neuroendocrine Tumors of the Jejunum, Ileum, Appendix, and Cecum
J. Philip Boudreaux,David S. Klimstra,Manal M. Hassan,Eugene A. Woltering,Robert T. Jensen,Stanley J. Goldsmith,Charles Nutting,David L. Bushnell,Martyn Caplin,James C. Yao +9 more
TL;DR: Well-differentiated neuroendocrine tumors (NETs) of the jejunum, ileum, and appendix are also collectively known as midgut carcinoids and have substantial risk of relapse after resection and need to be followed for at least 7 years.
Journal ArticleDOI
Biochemical Testing for Neuroendocrine Tumors
Aaron I. Vinik,Maria P. Silva,Eugene A. Woltering,Vay Liang W. Go,Richard R.P. Warner,Martyn Caplin +5 more
TL;DR: This chapter presents a new approach ranging from biochemical markers that relate to symptoms to the use of markers that facilitate decision making with regard to optimizing the choices of therapy from the complex arrays of intervention.
Journal ArticleDOI
Circulating markers of prognosis and response to treatment in patients with midgut carcinoid tumours
G B Turner,Brian T. Johnston,David R. McCance,Ann McGinty,R. G. P. Watson,Christopher Patterson,Joy Ardill +6 more
TL;DR: This is the first paper to support a survival advantage in patients in whom plasma NKA is altered by somatostatin analogues, and time dependent covariate analysis concluded that survival was better predicted by the most recent Plasma NKA value rather than by the initial value.
Journal ArticleDOI
Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior.
Thomas M. O'Dorisio,Siegfried R. Krutzik,Eugene A. Woltering,Erika Lindholm,Saju Joseph,Abby E. Gandolfi,Yi-Zarn Wang,J. Phillip Boudreaux,Aaron I. Vinik,Vay Liang W. Go,James R. Howe,Thor Halfdanarson,M. Sue O'Dorisio,Gregg Mamikunian +13 more
TL;DR: This highly specific, sensitive pancreastatin assay can detect small changes in liver tumor progression and is up to 100-fold more sensitive and specific than CgA assays in the United States.